Product Overview

2-Bromo-4-methylanisole is an organic compound with the molecular formula C₈H₉BrO and molecular weight of 201.06 g/mol. This colorless to light yellow liquid is a valuable intermediate in pharmaceutical and agrochemical research. The compound features a methoxy group, a bromine atom, and a methyl group on the aromatic ring.

Synthetic Process

• Methylation: 2-Bromo-4-methylphenol is methylated using dimethyl sulfate or methyl iodide in the presence of a base

• Purification: The crude product is purified by fractional distillation

• Quality Control: The final product is analyzed to ensure ≥98.0% purity by GC

Mechanism of Action

• Cross-Coupling Substrate: The aryl bromide enables Suzuki-Miyaura and other coupling reactions

• Ether Reactivity: The methoxy group provides electron donation to the aromatic ring

• Electrophilic Aromatic Substitution: The methoxy and methyl groups direct electrophilic substitution to specific positions

Research Applications & Market Significance

• Pharmaceutical Research: Building block for drug discovery programs

• Agrochemical Synthesis: Intermediate for pesticides and herbicides

• Organic Synthesis: Versatile intermediate for functionalized aromatic compounds

• Material Science: Used in the preparation of specialty polymers

Quality Specifications

• Purity: ≥98.0% determined by GC

• Boiling point: 110-112°C (10 mmHg)

• Density: 1.372 g/mL at 25°C

• Refractive index: n²⁰/D 1.550

• Storage: 2-8°C, sealed, protected from light

• Stable for 24 months when properly stored

Packaging & Shipping

• Research quantities: 25g, 100g amber glass bottles

• Bulk quantities: 500g, 1kg amber glass bottles

• Shipped at ambient temperature