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DL-α-Tocopherol10191-41-0

Name: DL-α-Tocopherol10191-41-0
Brand: OORENT
SKU: pr2610091313
Price: 33 USD
Availability: InStock

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Unit Price:

$33-34/MT FOB

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CAS No.:

10191-41-0

Grade:

Pharmaceutical Grade

Content:

99.5%

Port:

shanghai

Brand:

OORENT

Packaging:

Vial/Bottle/Bag/Carton

Sample Available:

Yes

Price valid (until):

2026-11-09

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Payment Terms:

100% TT in advance

Average Lead Time:

10 days

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Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
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Description

Product Detailv

DL-α-Tocopherol Basic information

Product Name:	DL-α-Tocopherol
Synonyms:	ALL-RAC-ALPHA-TOCOPHEROL;(+/-)-ALPHA-TOCOPHEROL;(+/-)-ALPHA-TOCOFEROL;ALPHA-TOCOPHEROLUM;ALPHA-DL-TOCOPHEROL;5,7,8-TRIMETHYLTOCOL;IRGANOX E 201;DL-TOCOPHEROL
CAS:	10191-41-0
MF:	C29H50O2
MW:	430.71
EINECS:	233-466-0
Product Categories:	Other APIs;Antioxidant;Organics;Biochemistry;Vitamins;MX
Mol File:	10191-41-0.mol

DL-α-Tocopherol Chemical Properties

Melting point	2-4°C
Boiling point	200-220°C 0,1mm
alpha	[α]D20 - 0.02 - +0.02゜ (neat)
density	0.950 g/mL at 20 °C(lit.)
vapor pressure	<1 hPa ( 20 °C)
refractive index	n20/D 1.506
Fp	240°C
storage temp.	2-8°C
solubility	H2O: insoluble
pka	11.40±0.40(Predicted)
form	Pale yellow oil
color	Colourless to Dark Yellow
PH	7 (20°C, 50g/L in H2O, slurry)
Odor	at 100.00%. bland
biological source	synthetic
Water Solubility	Miscible with chloroform, vegetable oils, ether, acetone and alcohol. Immiscible with water.
Sensitive	Light Sensitive
Merck	14,9495
BRN	94012
Major Application	food and beverages
Cosmetics Ingredients Functions	SKIN CONDITIONING - OCCLUSIVE ANTIOXIDANT FRAGRANCE SKIN CONDITIONING - MISCELLANEOUS
InChI	1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3
InChIKey	GVJHHUAWPYXKBD-IEOSBIPESA-N
SMILES	CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(O)c(C)c(C)c2O1
LogP	12.2 at 25℃
CAS DataBase Reference	10191-41-0(CAS DataBase Reference)
EPA Substance Registry System	2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)- (10191-41-0)

Safety Information

Hazard Codes	Xi,T,F
Risk Statements	36/37/38-39/23/24/25-23/24/25-11
Safety Statements	26-37/39-45-36/37-16-7
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	1
RTECS	GA8746000
F	8-10-23
Autoignition Temperature	280°C
TSCA	TSCA listed
HS Code	29362800
Storage Class	10 - Combustible liquids
Hazard Classifications	Skin Sens. 1
Hazardous Substances Data	10191-41-0(Hazardous Substances Data)

MSDS Information

Provider	Language
ALFA	English

DL-α-Tocopherol Usage And Synthesis

Chemical Properties	1mg = 1.1 IU
Chemical Properties	Alpha tocopherol is a natural product. The PhEur 6.0 describes alpha-tocopherol as a clear, colorless or yellowish-brown, viscous, oily liquid.
Uses	dl-α-Tocopherol is the racemic analog of α-Tocopherol (T526125), the most bioactive of the naturally occurring forms of Vitamin E. Richest sources are green vegetables, grains, and oils, particularly palm, safflower and sunflower oils. dl-α-Tocopherol is an antioxidant that protects cell membrane lipids from oxidative damage.
Uses	DL-α-Tocopherol is used as an antioxidant that protects cell membrane lipids from oxidative damage.
Uses	These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Definition	ChEBI: 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-ol is a tocopherol.
Production Methods	Naturally occurring tocopherols are obtained by the extraction or molecular distillation of steam distillates of vegetable oils; for example, alpha tocopherol occurs in concentrations of 0.1–0.3% in corn, rapeseed, soybean, sunflower, and wheat germ oils.Beta and gamma tocopherol are usually found in natural sources along with alpha tocopherol. Racemic synthetic tocopherols may be prepared by the condensation of the appropriate methylated hydroquinone with racemic isophytol.
General Description	TGF-β3 (transforming growth factor-β3) belongs to the TGF β superfamily. The TGFβ3 gene is mapped to human chromosome 14q24.3
Flammability and Explosibility	Non flammable
Pharmaceutical Applications	Alpha tocopherol is primarily recognized as a source of vitamin E, and the commercially available materials and specifications reflect this purpose. While alpha tocopherol also exhibits antioxidant properties, the beta, delta, and gamma tocopherols are considered to be more effective as antioxidants. Alpha-tocopherol is a highly lipophilic compound, and is an excellent solvent for many poorly soluble drugs.Of widespread regulatory acceptability, tocopherols are of value in oil- or fat-based pharmaceutical products and are normally used in the concentration range 0.001–0.05% v/v. There is frequently an optimum concentration; thus the autoxidation of linoleic acid and methyl linolenate is reduced at low concentrations of alpha tocopherol, and is accelerated by higher concentrations. Antioxidant effectiveness can be increased by the addition of oil-soluble synergists such as lecithin and ascorbyl palmitate. Alpha tocopherol may be used as an efficient plasticizer. It has been used in the development of deformable liposomes as topical formulations. d-Alpha-tocopherol has also been used as a non-ionic surfactant in oral and injectable formulations.
Biochem/physiol Actions	TGF-β3 (transforming growth factor-β3) regulates lymphocyte proliferation, apoptosis, hematopoiesis and embryogenesis to maintain immune homeostasis. TGF-β plays an important role in cell growth, differentiation, and survival. TGF-β3 specifically promotes chondrogenic differentiation.TGF-β3 is a strong growth inhibitor for normal and transformed epithelial, lymphoid, fibroblast, and keratinocyte cells. TGF-2 inhibits antitumor action of NK (natural killer) cells, T-cells, macrophages, monocytes and neutrophils. TGF-β3 is a tumor suppressor in the early stages of carcinogenesis, but in the later stages acts as a tumor promoter by inducing epithelial-mesenchymal transition and stimulating angiogenesis. TGF-β isoforms is known to participate in wound healing and tissue fibrosis. TGF-β3 is crucial for tissue restoration and scarless tissue repair. Mutation in the TGFβ3 gene is associated with development of non-syndromic cleft palate only (NS CPO), a rare congenital disease.
Safety	Tocopherols (vitamin E) occur in many food substances that are consumed as part of the normal diet. The daily nutritional requirement has not been clearly defined but is estimated to be 3.0–20.0 mg. Absorption from the gastrointestinal tract is dependent upon normal pancreatic function and the presence of bile. Tocopherols are widely distributed throughout the body, with some ingested tocopherol metabolized in the liver; excretion of metabolites is via the urine or bile. Individuals with vitamin E deficiency are usually treated by oral administration of tocopherols, although intramuscular and intravenous administration may sometimes be used. Tocopherols are well tolerated, although excessive oral intake may cause headache, fatigue, weakness, digestive disturbance, and nausea. Prolonged and intensive skin contact may lead to erythema and contact dermatitis. The use of tocopherols as antioxidants in pharmaceuticals and food products is unlikely to pose any hazard to human health since the daily intake from such uses is small compared with the intake of naturally occurring tocopherols in the diet. The WHO has set an acceptable daily intake of tocopherol used as an antioxidant at 0.15–2.0 mg/kg body-weight.
storage	Tocopherols are oxidized slowly by atmospheric oxygen and rapidly by ferric and silver salts. Oxidation products include tocopheroxide, tocopherylquinone, and tocopherylhydroquinone, as well as dimers and trimers. Tocopherol esters are more stable to oxidation than the free tocopherols but are in consequence less effective antioxidants. Tocopherols should be stored under an inert gas, in an airtight container in a cool, dry place and protected from light.
Purification Methods	Dissolve dl--tocopherol in anhydrous MeOH (15mL/g) cool to -6o for 1hour, then chill in a Dry-ice/acetone bath; crystallisation is induced by scratching with a glass rod. The dl--acetate [52225-20-4] (see DL-vitamin E actetate below) is a viscous yellow liquid with m -7o, b 184o/0.01mm, 224o/0.3mm, d 4 20 0.953, n D 20 1.496. It is used as a standard for Vitamin E activity where the unit of activity is attained with 1mg of pure dl--acetate. [Friedrich “Vitamins” Water de Guyter Publ, Berlin 1988, Beilstein 17/4 V 168.]
Incompatibilities	Tocopherols are incompatible with peroxides and metal ions, especially iron, copper, and silver. Tocopherols may be absorbed into plastic.
Regulatory Status	GRAS listed. Accepted in Europe as a food additive. Included in the FDA Inactive Ingredients Database (IV injections, powder, lyophilized powder for liposomal suspension; oral capsules, tablets, and topical preparations). Included in the Canadian List of Acceptable Non-medicinal Ingredients. Included in nonparenteral medicines licensed in the UK.
References	[1] Patent: WO2004/46127, 2004, A1. Location in patent: Page 6-7 [2] Journal of Catalysis, 2007, vol. 251, # 2, p. 388 - 399

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ECHEMI Editorial Reference

DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB[1].
Liquid|Slightly yellow to amber, nearly odourless, clear, viscous oil which oxidises and darkens on exposure to air or light
2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-ol is a tocopherol.|dl-alpha-Tocopherol is a synthetic form of vitamin E, a fat-soluble vitamin with potent antioxidant properties. Considered essential for the stabilization of biological membranes (especially those with high amounts of polyunsaturated fatty acids), d-alpha-Tocopherol is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, resulting in a decrease in prostaglandin production. Vitamin E also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription. (NCI04)

Basic Info

Product Name:

DL-α-Tocopherol

Other Name:

2H-1-Benzopyran-6-ol,3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-;6-Chromanol,2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-;3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol;dl-α-Tocopherol;(±)-α-Tocopherol;Ephanyl;DL-α-Tocopherol;all-rac-α-Tocopherol;Ronotec DF 120;Ronotec 201;Rac-α-Tocopherol;Ronotec 202;3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ol;Uvinul 2000AO;Elementol B;Elementol R;Elementol Basic;Irganox E 210;2,5,7,8-Tetramethyl-2-(4′,8′,12′-trimethyltridecyl)chroman-6-ol;2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)chroman-6-ol;Irganox LE 307;364-50-1;4072-33-7;16826-11-2;25094-97-7;181591-70-8

CAS No.:

10191-41-0

Molecular Formula:

C29H50O2

InChIKeys:

InChIKey=GVJHHUAWPYXKBD-UHFFFAOYSA-N

Molecular Weight:

430.71

Exact Mass:

430.71

BRN:

94012

EC Number:

233-466-0

UNII:

7QWA1RIO01

NSC Number:

755839|82623|20812

DSSTox ID:

DTXSID8021355

NCI Thesaurus Code:

C74578

Color/Form:

Slightly viscous, pale yellow oil

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

29.5

XLogP3:

log Kow = 12.2 (est)

Appearance:

Liquid

Density:

0.950 g/mL at 20 °C(lit.)

Melting Point:

2-4°C

Boiling Point:

205-210 °C @ Press: 0.02 Torr

Flash Point:

240°C

Refractive Index:

n20/D 1.506

Water Solubility:

Miscible with chloroform, vegetable oils, ether, acetone and alcohol. Immiscible with water.

Storage Conditions:

2-8°C

Vapor Pressure:

1.4X10-8 mm Hg at 25 °C (est)

Specific rotation:

[α]D/25 0° ± 0,05° (1 in 10 solution in chloroform)

Henrys Law Constant:

Henry's Law constant = 7.9X10-5 atm-cu m/mole 25 °C (est)

Dissociation Constants:

pKa = 10.8 (hydroxy) (est)

Collision Cross Section:

219.7 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Experimental Properties:

Hydroxyl radical reaction rate constant = 2.3X10-10 cu cm/molec-sec at 25 °C (est)

See More DL-α-Tocopherol Properties 

Hazard Identification

Classification of the substance or mixture

Skin sensitization, Sub-category 1B

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H317 May cause an allergic skin reaction
Prevention	P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P333+P317 If skin irritation or rash occurs: Get medical help. P321 Specific treatment (see ... on this label). P362+P364 Take off contaminated clothing and wash it before reuse.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8 deg C.

See More DL-α-Tocopherol Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10 days

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

17 Inquiries

Country	Product	Purchase Quantity	Date Posted
United Kingdom	DL-alpha-Tocopherol	60 KG	Sep 30, 2026
India	Vitamin E	1.00 MT	Apr 27, 2025
India	Vitamin E oil pure	10 TON	Apr 22, 2025
Egypt	Vitamin E oily	5 TON	Dec 17, 2024
Indonesia	Dl-Alpha Tocopherol	50 G	Jun 7, 2024
Indonesia	Vitamin E 50% Oil Certified RSPO Mix Tocopherol Tocotrienol for Supplement Amber Liquid Gold Tri.E	100 G	Nov 2, 2023
Indonesia	Vitamin E 50% oil	500 G	Nov 1, 2023
Malaysia	High Quality Raw Material Vitamin e Oil price Dl-alpha tocopheryl Acetate	100 KG	Oct 27, 2023
India	Synthetic Vitamin E (DL-alpha-Tocopherol)	100 G	Sep 2, 2026
Pakistan	Vitamin E	10.00 MT	Feb 14, 2025
Sri Lanka	Alpha - Tocopherol -Vitamin E	1000.00 KG	Feb 13, 2025
India	DL Alpha Tocopherol	1.00 KG	Mar 1, 2024
Indonesia	Vitamin E 50% Oil Certified RSPO Mix Tocopherol Tocotrienol for Supplement Amber Liquid Gold Tri.E	100 G	Oct 31, 2023
Sri Lanka	Alpha - Tocopherol -Vitamin E	1000.00 KG	Feb 12, 2025
India	Tocopherol	5 TON	Feb 7, 2025
Peru	Vitamin Factory Direct Sale Bulk Mixed Tocopherol Powder Natural Vitamin E D-alpha Tocopherol	25 KG	Nov 7, 2023
India	D-Alpha Tocopherol	2 MT	Nov 20, 2023

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DL-α-Tocopherol10191-41-0

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