Sodium dimethyldithiocarbamate

143.21

142.984

204-876-7

769GO8W6QQ

DTXSID6027050

Yellow liquid (40% w/w aqueous solution)

29302000

36.3

1.03040

Crystals or liquid. Becomes anhydrous at 266°F. (NTP, 1992)

1.18 g/cm³

106-108 °C

130ºC

32ºC

Slowly decomposes in aqueous solution to form carbon disulfide and methylamine or other amines. Such decompositions are accelerated by acids.

0-6°C

pH = 10.1 (1% aqueous solution); pH 12.6 (32% aqueous solution)

pKa = 5.4 for the organic portion /Estimated/

Slowly decomposes in aqueous solution to form carbon disulfide and methylamine or other amines. Such decompositions are accelerated by acids.

Thiocarbamate Esters and Salts/Dithiocarbamate Esters and Salts

Flammable gases are generated by the combination with aldehydes, nitrides, and hydrides. Incompatible with acids, peroxides, and acid halides.

III

9

UN 3082 9 / PGIII

-

22-36-50

26-36-61

FD3500000

Xn,N

Stable under normal temperatures and pressures.

P260, P264, P270, P273, P280, P301+P312, P302+P352, P309+P311, P314, P321, P330, P332+P313, P362, P391, P405, P501

H302

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Sodium dimethyldithiocarbamate is an indirect food additive for use only as a component of adhesives.

EPA/Office of Pollution Prevention and Toxics; High Production Volume (HPV) Challenge Program's Robust Summaries and Test Plans. Available from: http://www.epa.gov/chemrtk/viewsrch.htm on Carbamodithioic acid, dimethyl-, sodium salt as of November 3, 2004.|The U.S. high production volume (HPV) chemicals are those which are manufactured in or imported into the United States in amounts equal to or greater than one million pounds per year. Robust Summaries include health effects, ecotoxicity data, and environmental fate information for selected chemicals. EPA/Office of Pollution Prevention and Toxics; High Production Volume (HPV) Challenge Program's Robust Summaries and Test Plans. Available from: http://www.epa.gov/chemrtk/viewsrch.htm on Carbamodithioic acid, dimethyl-, sodium salt as of November 3, 2004.

Flash point data for this compound are not available. It is probably not flammable. (NTP, 1992)

|Warning|H302 (21.82%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P273, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P321, P330, P332+P313, P362, P391, and P501|Aggregated GHS information provided by 330 companies from 17 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P260, P264, P270, P273, P280, P301+P312, P302+P352, P309+P311, P314, P321, P330, P332+P313, P362, P391, P405, and P501|Danger|P260, P264, P270, P301+P312, P307+P311, P314, P321, P330, P405, and P501

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this material in a refrigerator. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

LD50 Rat oral 1000 mg/kg|LD50 Mouse 1500 mg/kg|LD50 Mouse 573 mg/kg|LD50 Rat dermal >5000 mg/kg bw

/AQUATIC SPECIES/ Early life stages of Salmo gairdneri, from the fertilized egg to the early fry stage, were continuously exposed to various dialkyldithiocarbamates (DDCs), ethylenebisdithiocarbamates (BDCs) and a number of degradation products. Both DDCs and BDCs induced embryotoxicity, but DDCs were generally found to be more toxic than BDCs. For some DDCs adverse effects, below ppb-level were observed. All compounds, including carbon disulfide, were shown to have teratogenic properties. The most striking effects were severe spinal and vertebral abnormalities, mostly associated with retarded yolk sac resorption. /Dialkyldithiocarbamates/

Sodium N,N-dimethylthithiocarbamate's production and use as a disinfectant, corrosion inhibitor, coagulant, vulcanizing agent, chelating agent, and fungicide(1) may result in its release to the environment through various waste streams(SRC). Sodium N,N-dimethylthithiocarbamate is used in water treatment, the rubber industry and is a registered biocide for cutting oils and aqueous systems in industries such as leather tanning and paper manufacturing(2). It is also used as an antimicrobial agent in paints(3).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 2.2(SRC), determined from a water solubility of 1X10+6 mg/L (miscible)(2) and a regression-derived equation(3), indicates that sodium N,N-dimethylthithiocarbamate is expected to have very high mobility in soil(SRC). Hydrolysis half-life of 18 minutes, 25.9, and 433.3 hours were reported for sodium N,N-dimethylthithiocarbamate at pH 5, 7, and 9, respectively(2); this compound would be expected to hydrolyze in moist neutral or acidic soils(SRC). The estimated pKa of sodium N,N-dimethydithiocarbamate is 5.4(6), indicating that this compound will primarily exist in the dissociated form at environmentally relevant pHs; therefore, volatilization from moist soil surfaces is not expected to be an important fate process(SRC). Sodium N,N-dimethylthithiocarbamate is not expected to volatilize from dry soil surfaces since it is a salt and will be nonvolatile(SRC). Photolysis in aqueous solution and on soil was found to be an important degradation process for a related compound, ziram(4), and may also be important for sodium N,N-dimethylthithiocarbamate(SRC). Sodium N,N-dimethylthithiocarbamate, present at 100 mg/L, reached 2% of its theoretical BOD in 28 days at 25 °C using an activated sludge inoculum at 30 mg/L and the Japanese MITI test(5); however, this result may be due to the biocidal properties of sodium N,N-dimethylthithiocarbamate(SRC). In an anaerobic degradation test with sodium N,N-dimethylthithiocarbamate, tetramethyl thiuram disulfide and tetramethyl thiuram monosulfide were the major decomposition products(2).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 2.2(SRC), determined from a water solubility of 1X10+6 mg/L (miscible)(2) and a regression-derived equation(3), indicates that sodium N,N-dimethylthithiocarbamate is not expected to adsorb to suspended solids and sediment(SRC). The estimated pKa of sodium N,N-dimethylthithiocarbamate is 5.4(6), indicating that this compound will primarily exist in the dissociated form at environmentally relevant pHs; therefore, volatilization from moist soil surfaces is not expected to be an important fate process(SRC). Bioconcentration is not expected to be a significant fate for sodium N,N-dimethylthithiocarbamate, due to its rapid hydrolysis at neutral and acidic pH(2) and its ionic character(SRC). Hydrolysis half-life of 18 minutes, 25.9, and 433.3 hours were reported for sodium N,N-dimethylthithiocarbamate at pH 5, 7, and 9, respectively(2). Photolysis in aqueous solution was found to be an important degradation process for a related compound, ziram(4), and may also be important for sodium N,N-dimethylthithiocarbamate(SRC). Sodium N,N-dimethylthithiocarbamate, present at 100 mg/L, reached 2% of its theoretical BOD in 28 days at 25 °C using an activated sludge inoculum at 30 mg/L and the Japanese MITI test(5); however, this result may be due to the biocidal properties of sodium N,N-dimethylthithiocarbamate(SRC). In an anaerobic degradation test with sodium N,N-dimethylthithiocarbamate, tetramethyl thiuram disulfide and tetramethyl thiuram monosulfide were the major decomposition products(2).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), sodium N,N-dimethylthithiocarbamate will solely in the particulate phase in the ambient atmosphere, since it is a salt and will be nonvolatile(SRC). Particulate-phase sodium N,N-dimethylthithiocarbamate will be removed from the atmosphere by wet and dry deposition(SRC).

Hydrolysis half-lives of 18 minutes, 25.9, and 433.3 hours were reported for sodium N,N-dimethylthithiocarbamate at pH 5, 7, and 9, respectively(1). Photolysis in aqueous solution and on soil was found to be an important degradation process for a related compound, ziram(2), and may also be important for sodium N,N-dimethylthithiocarbamate(SRC).

The estimated pKa of sodium N,N-dimethylthithiocarbamate is 5.4(1), indicating that this compound will primarily exist in the dissociated form at environmentally relevant pHs. Bioconcentration is not expected to be a significant fate for sodium N,N-dimethylthithiocarbamate, due to its rapid hydrolysis at neutral and acidic pH(2) and its ionic character(SRC). Hydrolysis half-life of 18 minutes, 25.9, and 433.3 hours were reported for sodium N,N-dimethylthithiocarbamate at pH 5, 7, and 9, respectively(2).

The Koc of sodium N,N-dimethylthithiocarbamate is estimated as 2.2(SRC), using a water solubility of sodium N,N-dimethylthithiocarbamate(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that sodium N,N-dimethylthithiocarbamate is expected to have very high mobility in soil. Hydrolysis half-life of 18 minutes, 25.9, and 433.3 hours were reported for sodium N,N-dimethylthithiocarbamate at pH 5, 7, and 9, respectively(1);this compound would be expected to hydrolyze in moist neutral or acidic soils(SRC).

The estimated pKa of sodium N,N-dimethylthithiocarbamate is 5.4(1), indicating that this compound will primarily exist in the dissociated form at environmentally relevant pHs; therefore, volatilization from moist soil surfaces is not expected to be an important Sodium N,N-dimethylthithiocarbamate is not expected to volatilize from dry soil surfaces since it is a salt and will be nonvolatile(SRC).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 15,271 workers (2,653 of these are female) are potentially exposed to sodium N,N-dimethylthithiocarbamate in the US(1). Occupational exposure to sodium N,N-dimethylthithiocarbamate may occur through inhalation and dermal contact with this compound at workplaces where sodium N,N-dimethylthithiocarbamate is produced or used(SRC). Most large industrial users of sodium N,N-dimethylthithiocarbamate for water treatment use mechanized material handling systems, and exposure to workers would be expected to be minimal(2). The greatest potential for dermal and inhalation exposure to sodium N,N-dimethylthithiocarbamate is expected at the packing station at the manufacturing site and to a lesser extent during activities at the consumer site(2).

...Partition of Mn in the presence of potassium ethylxanthate, sodium diethyldithiophosphate, sodium dimethyldithiocarbamate, and sodium diethyldithiocarbamate between octanol and Tris-HCl buffer showed formation of lipophilic complex with the latter two compounds, but not with the former. However, these four chelating agents all decreased Mn uptake in the /Brown/ trout /(Salmo trutta)/ by 40-45%. ...

ACUTE/CHRONIC HAZARDS: When heated to decomposition it emits very toxic fumes. (NTP, 1992)|Teratogens

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

For metals chelation use.|Carbamodithioic acid, N,N-dimethyl-, sodium salt (1:1): ACTIVE|Photodegradation product of tetramethylthioram disulfide.

Agrochemicals -> Fungicides|Health Hazards -> Teratogens