Span 60
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Span 60
structure -
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CAS No:
1338-41-6
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Formula:
C24H46O6
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Chemical Name:
Span 60
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Synonyms:
FEMA 3028;EMALEX SPE-100S;ARLACEL 60;SPAN(TM) 60;SPAN 60;SPAN(R) 60;SPAN NO 60;SORBITAN MONOSTEARATE
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CAS No:
Description
DryPowder, OtherSolid; PelletsLargeCrystals
Sorbitan monostearate has a bland odor and taste. It is a mixture of partial stearic and palmitic acid esters of sorbitol and its mono- and dianhydrides. For additional details of description, refer to Burdock (1997).
ChEBI: Sorbitan monostearate is a fatty acid ester.
Span 60 is a sorbitan monoester than is used as a non-ionic detergent.
Very mildly toxic by ingestion. Experimental reproductive effects. A skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
Span 60 Basic Attributes
430.62
430.329439
6820761
215-664-9
TSCA listed
DTXSID1027396
Cream coloured flakes
34021300
Characteristics
96.2
4.27260
DryPowder, OtherSolid; PelletsLargeCrystals
1.00
54-57 °C(lit.)
464.84°C (rough estimate)
>230 °F
1.4593 (estimate)
Soluble in ethanol (50 mg/ml), isopropanol, mineral oil and vegetable oil. Insoluble in water.
Store below +30°C.
<1.4 hPa (20 °C)
LD50 orally in Rabbit: 15900 mg/kg
Non flammable
Slight
BLAND TASTE
13.63[at 20 ℃]
HLB NUMBER 4.7; ACID NUMBER 5-10; SAPONIFICATION NUMBER 147-157; HYDROXYL NUMBER 235-260
Store below +30°C.
Safety Information
1
36/37/38
24/25
WG2933500
Stable. Combustible. Incompatible with strong oxidizing agents.
36/37/38
SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
Sorbitan monostearate is a food additive permitted in feed and drinking water of animals.|Sorbitan monostearate is a food additive permitted for direct addition to food for human consumption as a synthetic flavoring substance and adjuvant in accordance with the following conditions: a) they are used in the minimum quantity required to produce their intended effect, and otherwise in accordance with all the principles of good manufacturing practice, and 2) they consist of one or more of the following, used alone or in combination with flavoring substances and adjuvants generally recognized as safe in food, prior-sanctioned for such use, or regulated by an appropriate section in this part.|Sorbitan monostearate is a diluent in color additive mixtures for drug use exempt from certification.
Not Classified
A skin irritant.
Drug Information
The formulation and characterization of a novel anhydrous organogel formulated as a potential delivery vehicle from a solution of 2 nonionic surfactants, sorbitan monostearate (Span 60) and polysorbate 20 (polyoxyethylene sorbitan monolaurate; Tween 20), in hexadecane at 60DGC, which cools to a white, semi-solid, thermoreversible gel at room temperature, are described. The addition of an aqueous phase (water or niosome suspensions) up to 17% v/v to the oil phase at 60DGC produced water-in-oil and vesicle-in-water-in-oil systems, respectively. The release rate of hydrophilic solute from these gels was found to be lowest when a disperse system of spherical water droplets in the continuous oil phase was formed at high temperatures, compared to the faster release from the gel where the fibril structures acted as nearly continuous aqueous channels running through the organic medium, providing a means of traversing the oil phase.
1. 1= PRACTICALLY NON-TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) ABOVE 15 G/KG, MORE THAN 1 QT FOR 70 KG PERSON (150 LB).
WHEN DIGESTED, BOTH THE FATTY ACID AND THE POLYHYDRIC ALCOHOL SORBITAN ARE ABSORBED, BUT THE LATTER IS COMPLETELY EXCRETED IN URINE.
...MAN HAS BEEN FED WITH IMPUNITY SINGLE DOSES OF 20 G OR DAILY DOSES OF 6 G FOR 1 MONTH.|Sorbitan monostearate increased gastric motility in two individuals given high single oral doses. Some indication of weak skin sensitization potential has been observed in man.
sorbitan monostearate
Span 60 Use and Manufacturing
One-step method is to add equimolar fatty acid, sorbitol and appropriate amount of catalyst sodium hydroxide to the reactor, under the protection of nitrogen flow, heated to 190 ℃ to start dehydration, esterification reaction; when heated to 230 ~ 250 ℃, While esterifying, the molecules are dehydrated into anhydride within the molecule, the reaction time is about 5-7 hours; after the reaction is completed, it is cooled to 85-95°C, and the appropriate amount of hydrogen peroxide is added for decolorization for 30 minutes to obtain the product. Anhydride first and esterification Put 320kg of 50% sorbitol in a dehydration pot, add appropriate amount of phosphoric acid, dehydrate at 100~150℃ under reduced pressure (5332.9Pa) to produce sorbitan; another 290kg is put into the esterification pot Stearic acid, heated and melted, stirred, and added sorbitan and an appropriate amount of 50% sodium hydroxide solution, and reacted at 170~210℃ for about 4h. When the acid value of the reaction liquid was <5, the reaction was ended; cooled to 110℃ , Add 30% hydrogen peroxide 2kg to decolor (Te can be decolorized with activated carbon), and finally put the material in the cooling plate while hot, and pulverize to get about 395kg of powdery product. First esterify and then form an anhydride at 200~260℃, equimolar stearic acid, sorbitol and an appropriate amount of alkaline catalyst sodium hydroxide are used for esterification. When the acid value is less than 10, add acid catalyst phosphoric acid, and then The product is dehydrated into anhydride at 180~240℃.
Lonzest(R) SMS is used as a pigment dispersion additive for PP color concentrates and as an antistatic agent for PVC.
Agricultural chemicals (non-pesticidal)
Cleaning and furnishing care products
Glycomul(R) S KFG (Span 60) is used as emulsifier for baked goods, icings & filings and whipped toppings. It is also used as a rehydration aid (production of active dry yeast) and as synthetic flavoring substances and adjuvants.It has only a very faint, oily-waxy odor, and a bitter taste in concentrations higher than 1000 ppm. However, its insolubility in water, and the fact that it is used mostly with large amounts of sugar (and acid) account for the much higher use level without any serious influence upon the flavor of the finished product.
1,000,000 - 10,000,000 lb|(1972) 3.60X10+9 GRAMS|(1975) PROBABLY GREATER THAN 2.27X10+6 GRAMS
A TYPICAL FLUID EMULSION SHORTENING FORMULATION CONTAINS 1.45% SORBITAN MONOSTEARATE. /FROM TABLE/|GRADES: TECHNICAL; FCC
Agriculture, forestry, fishing and hunting|Sorbitan, monooctadecanoate: ACTIVE|/IT IS/ A FOOD ADDITIVE PERMITTED IN FEED & DRINKING WATER OF ANIMALS AND/OR FOR TREATMENT OF FOOD PRODUCING ANIMALS; /IT IS/ ALSO PERMITTED IN FOOD FOR HUMAN CONSUMPTION.|...SURFACTANTS /LIKE SORBITAN MONOSTEARATE/ ARE FREQUENTLY USED /IN BAKING/ IN CONJUNCTION WITH MONO- & DIGLYCERIDES & WITH EACH OTHER.|OF THE SEVERAL EMULSIFIERS AVAILABLE FOR BAKERS' CAKES, SORBITAN MONOSTEARATE & POLYOXYETHYLENE SORBITAN MONOSTEARATE HAVE BEEN FOUND ESP EFFECTIVE. THESE EMULSIFIERS ARE ALMOST ALWAYS EMPLOYED IN COMBINATION TO GAIN SIGNIFICANT IMPROVEMENTS IN CAKE QUALITY.|VOL & TEXTURE /OF CAKES/ ARE AIDED BY INCLUSION OF SORBITAN MONOSTEARATE & POLYSORBATE 60...|For more General Manufacturing Information (Complete) data for SORBITAN MONOSTEARATE (6 total), please visit the HSDB record page.
GRAVIMETRIC METHOD, APPLICABLE TO SHORTENING AND FOOD OILS.
EPA Safer Chemical Functional Use Classes -> Surfactants|Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern|Cosmetics -> Emulsifying
Food Additives -> EMULSIFIER;
Drug Function and Efficacy
This product is a broad-spectrum antifungal drug. Its mechanism is to selectively inhibit squalene epoxidase, which is necessary for the synthesis of ergosterol.
Registered Holders
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Zhongnuo Kailin Pharmaceutical Development (Suzhou) Co., Ltd.
Active
China
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Guangdong Runhua Chemistry Co., Ltd.
Active
China
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Nanjing Well Pharmaceutical Group Co., Ltd.
Inactive
China
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