(3-AMINO-PYRIDIN-4-YL)-METHANOL

White solid

Step 2: Solid compound 61 (9.5 g, 69 [MMOL)] was carefully added in 3 aliquots to a slurry of LiAIH4 (9.5 g, 250 [MMOL)] in dry THF (200 [ML).] The resulting hot mixture was stirred at RT for 2 days. After cooling in an ice bath, the reaction was quenched with careful sequential dropwise addition of water (10 [ML), ] followed by 15percent aqueous [NAOH] (10 [ML), ] then by water (30 [ML).] The resulting solid was filtered through a pad of Celite and washed several times with THF. The oil obtained after evaporation of the solvent solidified on standing. The reaction mixture was purified by flash chromatography on silica gel using 5percent CH30H (NH3) /EtOAc as eluent, yielding 6.21 g (72percent) of 62. LC-MS: m/z = 125 (M+1).Solid Compound 289 (9.5 gr.; 69 mmoles) was carefully added in three aliquots to a slurry of lithium aluminum hydride (9.5 gr.; 250 mmoles) in 200 ml of dry tetrahydrofuran. The resulting hot mixture was stirred at room temperature for two days. After cooling in an ice bath, the reaction was quenched with very careful sequential dropwise addition of 10 ml of water, followed by 10 ml of 15percent aqueous NaOH, then by 30 ml of water. The resulting solid was filtered through a pad of Celite and washed several times with THF. The oil obtained after evaporation of the solvent, solidified on standing. The reaction mixture was purified by flash chromatography on silica gel using 5percentMeOH(NH

Molecular Weight:124.14
XLogP3:-0.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:124.063662883
Monoisotopic Mass:124.063662883
Topological Polar Surface Area:59.1
Heavy Atom Count:9
Complexity:87.1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes