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FILGRASTIM

FILGRASTIM structure

CAS No:
121181-53-1
Formula:
W99
Chemical Name:
FILGRASTIM
Synonyms:
FILGRASTIM;n-l-methionyl-colony-stimulatingfactor(humanclone1034;Colony-stiMulating factor (huMan clone 1034), N-L-Methionyl- (9CI)
Categories:
Active Pharmaceutical Ingredients > Blood System Drugs

Description

Clear, colourless or slightly yellowish liquidFilgrastim is a recombinant human granulocyte colony stimulating factor (G-CSF) indicated as an adjunct to cancer chemotherapy for patients with non-myeloid malignancies. It reduces the duration of chemotherapy-induced neutropenia by forcing immature leucocytes to differentiate into neutrophils, thereby decreasing the incidence and length of infections.Bone pain is the most significant side effect.Chugai launched the second G-CSF, lenograstim,

FILGRASTIM Basic Attributes

Molecular Weight：

0.00000

HScode：

3002905150

Characteristics

PSA：

0.00000

XLogP3：

0.00000

Storage Conditions：

-70°C

Toxicity：

LD50 oral in rat: > 3mg/kg

Safety Information

Transport codes：

NONH for all modes of transport

FILGRASTIM Use and Manufacturing

Antineutropenic; hematopoietic stimulant.Filgrastim, G-CSF, Neupogen, stimulates the proliferation ofgranulocytes (especially neutrophils) by mobilizinghematopoietic stem cells in the bone marrow. The native protein is glycosylated.Filgrastim selectively stimulates proliferation and differentiationof neutrophil precursors in the bone marrow. Thisleads to the release of mature neutrophils into the circulationfrom the bone marrow. Filgrastim also affects mature neutrophilsby enhancing phagocytic