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Alphaxalone

Alphaxalone structure

CAS No:
23930-19-0
Formula:
C21H32O3
Chemical Name:
Alphaxalone
Synonyms:
Pregnane-11,20-dione,3-hydroxy-,(3α,5α)-;5α-Pregnane-11,20-dione,3α-hydroxy-;(3α,5α)-3-Hydroxypregnane-11,20-dione;3α-Hydroxy-5α-pregnane-11,20-dione;5α-Pregnane-3α-ol-11,20-dione;Alphaxalone;Alfaxalone;GR 2/234;5α-Pregnan-3α-ol-11,20-dione;5α-Alphaxalone;Alfadione
Categories:
Active Pharmaceutical Ingredients > Anesthetic Agents

Description

Alphaxolone is a corticosteroid hormone.|Alfaxalone is a DEA Schedule IV controlled substance. Substances in the DEA Schedule IV have a low potential for abuse relative to substances in Schedule III.|Alfaxalone, also known as alphaxalone or alphaxolone, is a neuroactive steroid and general anaesthetic. It is used in veterinary practice under the trade name Alfaxan, and is licensed for use in both dogs and cats. Along with alfadolone, it is also one of the constituents of anesthetic drug mixture althesin.|Alfaxalone is a synthetic neuroactive steroid, with anesthetic activity. Upon administration, alfaxalone binds to the gamma-aminobutyric acid (GABA)-A cell surface receptor, thereby enhancing the inhibitory actions of GABA-A in the brain. This leads to modulation of neuronal cell membrane chloride ion transport and induction and maintenance of anesthesia.

Alphaxalone Basic Attributes

Molecular Weight：

332.48

Exact Mass：

332.48

UNII：

BD07M97B2A

DEA Code Number：

2731

DSSTox ID：

DTXSID9022576

NCI Thesaurus Code：

C72161

ATC Code：

N - Nervous system

Characteristics

PSA：

54.4

XLogP3：

3.77420

Appearance：

white powder

Density：

1.112g/cm3

Melting Point：

172-174 °C

Boiling Point：

468.1ºC at 760 mmHg

Flash Point：

251ºC

Refractive Index：

1.532

Water Solubility：

chloroform: ≥5 mg/mL, clear, colorless

Storage Conditions：

Store at RT

Vapor Pressure：

9.95E-11mmHg at 25°C

Toxicity：

Oral-rat LD50: 297 mg/kg; Oral-Mouse LD50: 430 mg/kg

Flammability characteristics：

Flammable; burning produces irritating fumes

Specific rotation：

D26 +113.4° (c = 1.2 in chloroform).

Safety Information

Transport codes：

UN 2811 6.1/PG 3

wgk germany：

hazard class code：

safety instructions：

22-36

RTECS Number：

TU4157800

Marks：

Storage features：

Treasury is ventilated, low temperature and dry; stored separately from food materials

Precautionary statement(s)：

P264, P270, P301+P310, P321, P330, P405, P501

Hazard Statements：

H301

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 39 companies from 1 notifications to the ECHA C&L Inventory.

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH：

Endogenous compounds or drugs that affect neuronal excitability through modulation of specific ionotropic receptors (e.g., GABA-A RECEPTORS). Endogenous neurosteroids are steroid hormones de novo synthesized by neurons and glial cells from steroid metabolite precursors (e.g., PREGNENOLONE). (See all compounds classified as Neurosteroids.)|Agents that are capable of inducing a total or partial loss of sensation, especially tactile sensation and pain. They may act to induce general ANESTHESIA, in which an unconscious state is achieved, or may act locally to induce numbness or lack of sensation at a targeted site. (See all compounds classified as Anesthetics.)

MeSH Entry Terms：

alfaxalone

DEA Controlled Substances：

Alfaxalone|Alfaxan, 5Î±-pregnan-3Î±-ol-11,20-dione|2731|Schedule IV - Substances in the DEA Schedule IV have a low potential for abuse relative to substances in Schedule III.|No

Alphaxalone Use and Manufacturing

Uses

Anesthetic;nociception blocker

Use Classification：

Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Computed Properties

Molecular Weight:332.5
XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:332.23514488
Monoisotopic Mass:332.23514488
Topological Polar Surface Area:54.4
Heavy Atom Count:24
Complexity:569
Defined Atom Stereocenter Count:8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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