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Methergine

Methergine structure

CAS No:
57432-61-8
Formula:
C20H25N3O2.C4H4O4
Chemical Name:
Methergine
Synonyms:
Ergoline-8-carboxamide,9,10-didehydro-N-[(1S)-1-(hydroxymethyl)propyl]-6-methyl-,(8β)-,(2Z)-2-butenedioate (1:1) (salt);Ergonovine,methyl-,compd. with maleic acid;Indolo[4,3-fg]quinoline,ergoline-8-carboxamide deriv.;Methylergonovine maleate;Methylergometrine maleate;Methylergobasine maleate;Methergine;Erezin;Basofortina;Methergin;Ryegonovin;Spametrin F;Metenarin;7054-07-1;11042-54-9;31745-12-7;32537-89-6;78207-87-1
Categories:
Active Pharmaceutical Ingredients > Hormones and the Endocrine System

Description

Methylergometrine maleate (Methylergonovine maleate) is an ergot alkaloid and an active metabolite of Methysergide with vasoconstrictive and uterotonic activity. Methylergometrine maleate is a potent, selective and orally active 5-HT receptors antagonist with a pA2 value of 9.6. Methylergometrine maleate has antimigraine and dopaminergic activity. Methylergometrine maleate can used for the prevention and control of postpartum hemorrhage[1][2][3].

Methergine Basic Attributes

Molecular Weight：

455.5

Exact Mass：

455.20600

EC Number：

260-734-4

HScode：

2939690000

Characteristics

PSA：

143

XLogP3：

1.96530

Appearance：

white

Density：

1.2744 (rough estimate)

Melting Point：

1720C (dec)

Boiling Point：

638.4ºC at 760mmHg

Refractive Index：

1.6500 (estimate)

Water Solubility：

H2O: 25 mg/mL

Storage Conditions：

-20°C Freezer

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

UN 1544 6.1/PG 3

wgk germany：

hazard class code：

23/24/25-62

safety instructions：

36/37/39-45

RTECS Number：

KE5500000

Marks：

Precautionary statement(s)：

Missing Phrase - N15.00950417-P261-P280-P302 + P352 + P312-P304 + P340 + P312-P403 + P233

Hazard Statements：

H301 + H311 + H331-H361

Methergine Use and Manufacturing

A metabolite of Methysergide. Semisynthetic ergot alkaloid. Oxytocic