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4-epi-Oxytetracycline

4-epi-Oxytetracycline structure

CAS No:
14206-58-7
Formula:
C22H24N2O9
Chemical Name:
4-epi-Oxytetracycline
Synonyms:
2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-,(4R,4aR,5S,5aR,6S,12aS)-;2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-,[4R-(4α,4aβ,5β,5aβ,6α,12aβ)]-;Quatrimycin,hydroxy-;(4R,4aR,5S,5aR,6S,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide;4-epi-Oxytetracycline
Categories:
Active Pharmaceutical Ingredients > Antibiotics

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Description

greenish-beige to brownish powder

4-epi-Oxytetracycline Basic Attributes

Molecular Weight：

460.43396

Exact Mass：

460.43

UNII：

73VON8SRY5

HScode：

29413020

Characteristics

PSA：

202.84000

Appearance：

Greenish-beige to brownish Powder

Density：

1.71±0.1 g/cm3(Predicted)

Melting Point：

168°C

Boiling Point：

839.6±65.0 °C(Predicted)

Flash Point：

394ºC

Storage Conditions：

Hygroscopic, -20°C Freezer, Under Inert Atmosphere

Safety Information

Transport codes：

NONH for all modes of transport

Drug Information

MeSH Entry Terms：

4-EOTC

4-epi-Oxytetracycline Use and Manufacturing

Epioxytetracycline is a degradation product of oxytetracycline formed by the epimerisation of the dimethylamino group at C4 in solution at neutral to acidic pH. The epimerisation is associated with a loss of antibiotic activity. Epioxytetracycline is an important standard for monitoring oxytetracycline stability.

Computed Properties

Molecular Weight:460.4
XLogP3:-1.6
Hydrogen Bond Donor Count:7
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:2
Exact Mass:460.14818035
Monoisotopic Mass:460.14818035
Topological Polar Surface Area:202
Heavy Atom Count:33
Complexity:1000
Defined Atom Stereocenter Count:6
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes