 Home > Encyclopedia > Panipenem

Panipenem

Panipenem structure

CAS No:
87726-17-8
Formula:
C15H21N3O4S
Chemical Name:
Panipenem
Synonyms:
1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid,6-[(1R)-1-hydroxyethyl]-3-[[(3S)-1-(1-iminoethyl)-3-pyrrolidinyl]thio]-7-oxo-,(5R,6S)-;1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid,6-(1-hydroxyethyl)-3-[[1-(1-iminoethyl)-3-pyrrolidinyl]thio]-7-oxo-,[5R-[3(S*),5α,6α(R*)]]-;(5R,6S)-6-[(1R)-1-Hydroxyethyl]-3-[[(3S)-1-(1-iminoethyl)-3-pyrrolidinyl]thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid;RS 533;CS 533;Panipenem;98167-70-5
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Panipenem is an organic molecular entity.|Panipenem is a broad-spectrum parenteral carbapenem with activity against aerobic, anaerobic, gram-positive and gram-negative organisms including non-fermenters. Panipenem is often co-administered with betamipron to prevent nephrotoxicity.

Panipenem Basic Attributes

Molecular Weight：

339.41

Exact Mass：

339.41

UNII：

W9769W09JF

NCI Thesaurus Code：

C66303

Characteristics

PSA：

130

XLogP3：

-3.69

Density：

1.6±0.1 g/cm3

Melting Point：

198-200 °C (decomp)

Boiling Point：

555.5±60.0 °C at 760 mmHg

Flash Point：

289.7±32.9 °C

Refractive Index：

1.746

Toxicity：

Approx LD50 in male, female mice (mg/kg): 1700-2200, 1300-1700 i.v. (Kimura)

Safety Information

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH Entry Terms：

6-(1-hydroxyethyl)-2-(1--acetimidoylpyrrolidin-3-ylthio)-1-carbapen-2-em-3-carboxylic acid

Panipenem Use and Manufacturing

Panipenem is a broad spectrum carbapenem antibacterial and antimicrobial agent working against Gram-negative and Gram-positive organisms.

Computed Properties

Molecular Weight:339.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:339.12527733
Monoisotopic Mass:339.12527733
Topological Polar Surface Area:130
Heavy Atom Count:23
Complexity:606
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It has a broad-spectrum antibacterial effect on Gram-positive and Gram-negative bacteria including anaerobic bacteria, and its antibacterial activity is almost the same as that of imipenem; it is stable to beta-lactamase produced by various bacteria; it has a high affinity for penicillin-binding protein, which can hinder the synthesis of bacterial cell walls and thus play a bactericidal role.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Panipenem Betamipron for Injection
Ingredients	This product is a compound preparation, its components are panipenem and betamipron.
Indication	It can cause a decrease in the concentration of sodium valproate in the blood, leading to epileptic seizures.

Panipenem Betamipron for Injection
Ingredients	This product is a compound preparation, its components are panipenem and betamipron.
Indication	It can cause a decrease in the concentration of sodium valproate in the blood, leading to epileptic seizures.

Registered Holders

JEIL PHARMACEUTICAL CO.,LTD.

South Korea
Active

Recommended Suppliers of Panipenem

Guangzhou Yaoguang Technology Co., Ltd. Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Custom Synthetic Chemicals,Biological Stains,Pharmaceutical Intermediates,Cosmetic Grade Chemicals,Enzyme,Nucleosides,Indicators,Speciality Chemicals,Biological Chemicals,Enzyme Substrates

87726-17-8

CAS No.: 87726-17-8

Inquiry
HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Panipenem

CAS No.: 87726-17-8

Content: 99.00%

Inquiry