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Kanamycin sulfate salt

Kanamycin sulfate salt structure

CAS No:
25389-94-0
Formula:
C18H38N4O15S
Chemical Name:
Kanamycin sulfate salt
Synonyms:
KANAMYCIN MONOSULFATE GAMMA-IRRADIATED*M OLECULAR BI;KANAMYCIN MONOSULFATE FROM STREPTOMYCES KANAMYCETIC;KANAMYCIN MONOSULFATE, BPC GRADE;KANAMYCIN SOLUTION 50MG/ML (STERILE*FILT ERED) CELL;KANAMYCIN SULFATE USP(CRM STANDARD);KANAMYCIN SULFATE USP 99%;KANAMYCIN SULFATE, MOLECULAR BIOLOGY GRADE;KANAMYCIN SULFATE CELL CULTURE GRADE 99%
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Kanamycin sulfate is an aminoglycoside bacteriocidal antibiotic which acts by binding to the bacterial 30S ribosomes.

It has been well known as desirable antibiotics, which shows an obvious curative effect on serious infections caused by gram-negative bacteria such as Escherichia coil, Klebsiella, Proteus, Pneumonia, Enterobacter aerogenes and Shigella. Clinically, this substance is mainly used for infections caused by sensitive bacteria including pulmonary infection, urinary tract infection, biliary tract infection, sepsis, and abdominal cavity infection. For example, the effective antibacterial activity of kanamycin sulfate has been demonstrated by the treatment of acute gonorrheal urethritis in men, showing that a single parenterally administered dose of 2 mg of kanamycin sulfate cured 144 (93%) of 155 men with acute gonorrheal urethritis.1Moreover, kanamycin sulfate was found to be a valuable drug in the treatment of serious infections in infants and children through an analysis of 140 cases treated during a two-year period.2

Kanamycin was found by Umezawa et al. in the culture broth of Streptomyces kanamyceticus in 1957. It is produced with other components, kanamycins B (bekanamycin) and C, which are also separated during the purification. The compound shows much lower toxicity than the earlier aminoglycosides, streptomycin and neomycin, and strong activity against a wide range of gram-positive and gram-negative bacteria, including Mycobacterium. Kanamycin has been used clinically for treatment of such serious infections as dysentery, salmonellosis, and tuberculosis.

Off-white powder

A broadspectrum antibiotic.

Kanamycin sulfate salt Basic Attributes

Molecular Weight：

582.58

Exact Mass：

582.205444

EC Number：

246-933-9

DSSTox ID：

DTXSID1047524

Color/Form：

white to off-white

HScode：

29419020

Characteristics

PSA：

365.59000

XLogP3：

-4.06220

Appearance：

white to off-white powder

Density：

1.3619 (rough estimate)

Melting Point：

250°C

Boiling Point：

809.5ºC at 760 mmHg

Flash Point：

443.4ºC

Refractive Index：

117.5 ° (C=1, H2O)

Water Solubility：

Soluble in water at 10mg/ml

Storage Conditions：

2-8°C

Toxicity：

LD50 in mice: 20.7 g/kg orally; 1450 mg/kg i.p. (Zel'tser)

Critical Temperature & Pressure：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

22-24/25-45-53

RTECS Number：

NZ3225030

Marks：

Storage features：

Room temperature

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P201-P308 + P313

Hazard Statements：

GHS Classification：

|Danger|H360 (97.77%): May damage fertility or the unborn child [Danger Reproductive toxicity]|P201, P202, P281, P308+P313, P405, and P501|Aggregated GHS information provided by 180 companies from 12 notifications to the ECHA C&L Inventory.|H360 (100%): May damage fertility or the unborn child [Danger Reproductive toxicity]|Aggregated GHS information provided by 39 companies from 1 notifications to the ECHA C&L Inventory.

Kanamycin sulfate salt Use and Manufacturing

Antibiotic complex produced by Streptomyces kanamyceticus Okami & Umezawa from Japanese soil. Comprised of three components, kanamycin A, the major component, and kanamycins B and C, two minor congeners. Antibacterial.

Kanamycin monosulfate, is used as an aminoglycoside antibiotic. Kanamycin can be used as a selection agent in several types of isolation media.Kanamycin sulfate from Streptomyces kanamyceticus has been used in tissue culture media. Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene. It is recommended for use in cell culture applications at 100mg/mL.

Kanamycin sulfate is an antibacterial agent similar to neomycin.

Computed Properties

Molecular Weight:582.6
Hydrogen Bond Donor Count:13
Hydrogen Bond Acceptor Count:19
Rotatable Bond Count:6
Exact Mass:582.20543769
Monoisotopic Mass:582.20543769
Topological Polar Surface Area:366
Heavy Atom Count:38
Complexity:720
Undefined Atom Stereocenter Count:15
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Material

Ammonium chloride

Ethanol

Sodium bisulfite

Ferrous sulfate

Zinc sulfate

Drug Function and Efficacy

Not yet clear

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Kanamycin Sulfate Ointment
Ingredients	The kanamycin sulfate contained in this product, calculated as kanamycin (C18H36N4O11), should be 90.0% to 110.0% of the labeled amount.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	1g:10mg
Manufacturer	Guangxi LMZ Yikang Pharmaceutical Co., Ltd.

Kanamycin Sulfate Injection
Ingredients	Main ingredients: Kanamycin sulfate.
Indication	1. When used in combination with other aminoglycosides or applied topically or systemically one after the other, it may increase ototoxicity, nephrotoxicity and neuromuscular blocking effects. 2. When used in combination with neuromuscular blockers, it may aggravate neuromuscular blocking effects, leading to muscle weakness, respiratory depression, etc. 3. When used in combination with capreomycin, cisplatin, ethacrynic acid, furosemide or vancomycin (or norvancomycin), or applied topically or systemically one after the other, it may increase ototoxicity and nephrotoxicity. 4. When used topically or systemically with cephalothin or cefazolin, it may increase nephrotoxicity. 5. When used in combination with polymyxin injections, or applied topically or systemically one after the other, it may increase nephrotoxicity and neuromuscular blocking effects. 6. Other nephrotoxic and ototoxic drugs should not be used in combination with this product or applied one after the other, so as not to aggravate nephrotoxicity or ototoxicity. 7. When aminoglycosides and beta-lactams (cephalosporins and penicillins) are mixed, they may lead to mutual inactivation. When this product is used in combination with the above-mentioned antibiotics, it must be dripped in separate bottles. It is also not suitable to be infused in the same bottle with other drugs.
Specifications	2ml:0.5g (500,000 units)
Manufacturer	Guangdong Leiyunshang Pharmaceutical Co., Ltd.

Kanamycin Sulfate Eye Drops
Ingredients	The main ingredient of this product is kanamycin sulfate. It is a multi-component antibiotic containing three components A, B, and C, with A being the main ingredient.
Indication	1. When used in combination with other aminoglycosides or applied topically in sequence, it may increase ototoxicity, nephrotoxicity and neuromuscular blocking effects. 2. When used in combination with capreomycin, cisplatin, ethacrynic acid, furosemide or vancomycin (or norvancomycin), or applied topically in sequence, it may increase ototoxicity and nephrotoxicity. 3. When used topically with cephalothin or cefazolin, it may increase nephrotoxicity. 4. Other nephrotoxic and ototoxic drugs should be used with caution in combination or in sequence with this product to avoid aggravating nephrotoxicity or ototoxicity.
Specifications	8ml:40mg
Manufacturer	Changchun Dirui Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Fujian Fukang Pharmaceutical Co., Ltd.

China
Active
Zhejiang Hisun Pharmaceutical Co., Ltd.

China
Active
Chengdu Brilliant Pharmaceutical Co., Ltd.

China
Active

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