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Kanamycin sulfate

Kanamycin sulfate structure

CAS No:
25389-94-0
Formula:
C18H36N4O11.H2O4S
Chemical Name:
Kanamycin sulfate
Synonyms:
D-Streptamine,O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-,sulfate (1:1);Kanamycin,sulfate (1:1) (salt);Kanamycin A sulfate;D-Streptamine,O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-,sulfate (1:1) (salt);Kanamycin sulfate;Kanamytrex;Kantrex;Cantrex;Kano;Kanamycin monosulfate;Kantrim;Kanamycin A monosulfate;Kanacedin;Kanatrol;Cristalomicina;Kamycin;Otokalixin;Kanaqua;Kantrexil;Kanasig;Kantrox;Kasmynex;Kanescin;Kannasyn;Enterokanacin;Klebcil;Kanabristol;Ophtalmokalixan;Resistomycin;Kanicin;Kanachron;Kenendomycin;133-92-6;11025-66-4;11030-21-0;11033-61-7
Categories:
Active Pharmaceutical Ingredients > Antibiotics

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Description

Kanamycin sulfate is an aminoglycoside bacteriocidal antibiotic which acts by binding to the bacterial 30S ribosomes.

Kanamycin sulfate Basic Attributes

Molecular Weight：

582.58

Exact Mass：

582.205444

EC Number：

246-933-9

DSSTox ID：

DTXSID1047524

HScode：

2941902000

Characteristics

PSA：

365.59000

XLogP3：

-4.06220

Appearance：

white to off-white powder

Density：

1.3619 (rough estimate)

Melting Point：

250°C

Boiling Point：

809.5ºC at 760 mmHg

Flash Point：

443.4ºC

Refractive Index：

117.5 ° (C=1, H2O)

Water Solubility：

H2O: 10-50 mg/mL As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 5 days.

Storage Conditions：

2-8°C

Toxicity：

LD50 in mice: 20.7 g/kg orally; 1450 mg/kg i.p. (Zel'tser)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

22-24/25-45-53

RTECS Number：

NZ3225030

Marks：

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P201-P308 + P313

Hazard Statements：

H360

GHS Classification：

|Danger|H360 (97.77%): May damage fertility or the unborn child [Danger Reproductive toxicity]|P201, P202, P281, P308+P313, P405, and P501|Aggregated GHS information provided by 180 companies from 12 notifications to the ECHA C&L Inventory.|H360 (100%): May damage fertility or the unborn child [Danger Reproductive toxicity]|Aggregated GHS information provided by 39 companies from 1 notifications to the ECHA C&L Inventory.

Kanamycin sulfate Use and Manufacturing

Antibiotic complex produced by Streptomyces kanamyceticus Okami & Umezawa from Japanese soil. Comprised of three components, kanamycin A, the major component, and kanamycins B and C, two minor congeners. Antibacterial.

Computed Properties

Molecular Weight:582.6
Hydrogen Bond Donor Count:13
Hydrogen Bond Acceptor Count:19
Rotatable Bond Count:6
Exact Mass:582.20543769
Monoisotopic Mass:582.20543769
Topological Polar Surface Area:366
Heavy Atom Count:38
Complexity:720
Undefined Atom Stereocenter Count:15
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Material

Ammonium chloride

Ethanol

Sodium bisulfite

Ferrous sulfate

Zinc sulfate

Drug Function and Efficacy

Not yet clear

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Kanamycin Sulfate Ointment
Ingredients	The kanamycin sulfate contained in this product, calculated as kanamycin (C18H36N4O11), should be 90.0% to 110.0% of the labeled amount.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	1g:10mg
Manufacturer	Guangxi LMZ Yikang Pharmaceutical Co., Ltd.

Kanamycin Sulfate Injection
Ingredients	Main ingredients: Kanamycin sulfate.
Indication	1. When used in combination with other aminoglycosides or applied topically or systemically one after the other, it may increase ototoxicity, nephrotoxicity and neuromuscular blocking effects. 2. When used in combination with neuromuscular blockers, it may aggravate neuromuscular blocking effects, leading to muscle weakness, respiratory depression, etc. 3. When used in combination with capreomycin, cisplatin, ethacrynic acid, furosemide or vancomycin (or norvancomycin), or applied topically or systemically one after the other, it may increase ototoxicity and nephrotoxicity. 4. When used topically or systemically with cephalothin or cefazolin, it may increase nephrotoxicity. 5. When used in combination with polymyxin injections, or applied topically or systemically one after the other, it may increase nephrotoxicity and neuromuscular blocking effects. 6. Other nephrotoxic and ototoxic drugs should not be used in combination with this product or applied one after the other, so as not to aggravate nephrotoxicity or ototoxicity. 7. When aminoglycosides and beta-lactams (cephalosporins and penicillins) are mixed, they may lead to mutual inactivation. When this product is used in combination with the above-mentioned antibiotics, it must be dripped in separate bottles. It is also not suitable to be infused in the same bottle with other drugs.
Specifications	2ml:0.5g (500,000 units)
Manufacturer	Guangdong Leiyunshang Pharmaceutical Co., Ltd.

Kanamycin Sulfate Eye Drops
Ingredients	The main ingredient of this product is kanamycin sulfate. It is a multi-component antibiotic containing three components A, B, and C, with A being the main ingredient.
Indication	1. When used in combination with other aminoglycosides or applied topically in sequence, it may increase ototoxicity, nephrotoxicity and neuromuscular blocking effects. 2. When used in combination with capreomycin, cisplatin, ethacrynic acid, furosemide or vancomycin (or norvancomycin), or applied topically in sequence, it may increase ototoxicity and nephrotoxicity. 3. When used topically with cephalothin or cefazolin, it may increase nephrotoxicity. 4. Other nephrotoxic and ototoxic drugs should be used with caution in combination or in sequence with this product to avoid aggravating nephrotoxicity or ototoxicity.
Specifications	8ml:40mg
Manufacturer	Changchun Dirui Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Fujian Fukang Pharmaceutical Co., Ltd.

China
Active
Zhejiang Hisun Pharmaceutical Co., Ltd.

China
Active
Chengdu Brilliant Pharmaceutical Co., Ltd.

China
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