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Sufentanil citrate

Sufentanil citrate structure

CAS No:
60561-17-3
Formula:
C22H30N2O2S.C6H8O7
Chemical Name:
Sufentanil citrate
Synonyms:
Propanamide,N-[4-(methoxymethyl)-1-[2-(2-thienyl)ethyl]-4-piperidinyl]-N-phenyl-,2-hydroxy-1,2,3-propanetricarboxylate (1:1);R 30730 citrate salt;Sufentanil citrate;Sufentanyl citrate;Sufenta;R 33800;Sufentanil forte;Dzuveo;Sufenta forte
Categories:
Analytical Chemistry > Standard

Description

Crystalline Solid

Sufentanil citrate is an anilide.|Sufenta is a DEA Schedule II controlled substance. Substances in the DEA Schedule II have a high potential for abuse which may lead to severe psychological or physical dependence.|Sufentanil Citrate is the citrate salt form of sufentanil, a synthetic congener of fentanyl and related to the phenylpieridines, with analgesic property. Sufentanil citrate binds to and activates the mu-opioid receptor, thereby producing analgesia, respiratory depression, miosis, reduced gastrointestinal motility, and euphoria. In addition, this agent has a more rapid onset of action and shorter duration of action compared to fentanyl.|An opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent.

Sufentanil citrate Basic Attributes

Molecular Weight：

578.67

Exact Mass：

578.23000

EC Number：

262-295-4

UNII：

S9ZFX8403R

DEA Code Number：

9740

DSSTox ID：

DTXSID5048928

NCI Thesaurus Code：

C47731

ATC Code：

N01AH03

HScode：

2934910000

Characteristics

PSA：

193

XLogP3：

2.90420

Appearance：

white to beige

Melting Point：

96.60C

Boiling Point：

493.1ºC at 760 mmHg

Flash Point：

9℃

Water Solubility：

H2O: soluble1mg/mL, clear

Storage Conditions：

-20°C Freezer

Toxicity：

LD50 intravenous in dog: 14100ug/kg

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

3249

wgk germany：

hazard class code：

26/27/28-39/23/24/25-23/24/25-11

safety instructions：

26-27-28-36/37/39-45-36/37-16-7

Marks：

T+,T,F

Precautionary statement(s)：

P210-P260-P280-P301 + P310-P311

Hazard Statements：

H225-H301 + H311 + H331-H370

GHS Classification：

|Danger|H300+H310+H330 (90.48%): Fatal if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]|P260, P262, P264, P270, P271, P280, P284, P301+P310, P302+P350, P304+P340, P310, P320, P321, P322, P330, P361, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 42 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Drug Indication：

Management of acute moderate to severe pain.|Treatment of acute pain

MeSH：

Agents that are administered in association with anesthetics to increase effectiveness, improve delivery, or decrease required dosage. (See all compounds classified as Adjuvants, Anesthesia.)|Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS. (See all compounds classified as Analgesics, Opioid.)|Ultrashort-acting anesthetics that are used for induction. Loss of consciousness is rapid and induction is pleasant, but there is no muscle relaxation and reflexes frequently are not reduced adequately. Repeated administration results in accumulation and prolongs the recovery time. Since these agents have little if any analgesic activity, they are seldom used alone except in brief minor procedures. (From AMA Drug Evaluations Annual, 1994, p174) (See all compounds classified as Anesthetics, Intravenous.)|Agents that induce NARCOSIS. Narcotics include agents that cause somnolence or induced sleep (STUPOR); natural or synthetic derivatives of OPIUM or MORPHINE or any substance that has such effects. They are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS. (See all compounds classified as Narcotics.)

MeSH Entry Terms：

Citrate, Sufentanil

DEA Controlled Substances：

Sufentanil|Sufenta|9740|Schedule II - Substances in the DEA Schedule II have a high potential for abuse which may lead to severe psychological or physical dependence.|Yes

Sufentanil citrate Use and Manufacturing

Uses

Potent derivative of Fentanyl. Analgesic (narcotic). Controlled substance (opiate)

Use Classification：

Human drugs -> Dzuveo -> EMA Drug Category|Anesthetics -> Human pharmacotherapeutic group|Human Drugs -> EU pediatric investigation plans|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:578.7
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:13
Exact Mass:578.22980197
Monoisotopic Mass:578.22980197
Topological Polar Surface Area:193
Heavy Atom Count:40
Complexity:687
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes