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HT 2 Toxin

HT 2 Toxin structure

CAS No:
26934-87-2
Formula:
C22H32O8
Chemical Name:
HT 2 Toxin
Synonyms:
Trichothec-9-ene-3,4,8,15-tetrol,12,13-epoxy-,15-acetate 8-(3-methylbutanoate),(3α,4β,8α)-;Trichothec-9-ene-3α,4β,8α,15-tetrol,12,13-epoxy-,15-acetate 8-isovalerate;Isovaleric acid,8-ester with 12,13-epoxytrichothec-9-ene-3α,4β,8α,15-tetrol 15-acetate;Spiro[2,5-methano-1-benzoxepin-10,2′-oxirane],trichothec-9-ene-3,4,8,15-tetrol deriv.;3,4-Dihydroxy-15-acetoxy-8-(3-methylbutyryloxy)-12,13-epoxy-Δ9-trichothecene;HT 2 Toxin;Toxin HT 2;Mycotoxin HT 2;HT 2;NSC 278571;HT 2 mycotoxin;116163-63-4;61356-56-7;145427-92-5
Categories:
Analytical Chemistry > Standard

Description

HT-2 Toxin is an active, deacetylated metabolite of the T-2 toxin. HT-2 toxin inhibits protein synthesis and cell proliferation in plants[1][2].

HT 2 Toxin Basic Attributes

Molecular Weight：

424.48

Exact Mass：

424.48

EC Number：

200-835-2

NSC Number：

278571

HScode：

29329990

Characteristics

PSA：

114.82000

XLogP3：

2.27

Density：

1.3±0.1 g/cm3

Boiling Point：

537.1±50.0 °C at 760 mmHg

Flash Point：

2 °C

Refractive Index：

1.562

Storage Conditions：

−20°C

Safety Information

Packing level：

Hazard category：

6.1(a)

Transport codes：

UN 3462 6.1/PG 1

wgk germany：

hazard class code：

26/27/28-36/37/38-36-20/21/22-11

safety instructions：

22-26-36/37/39-45-36/37-16

RTECS Number：

YD0050000

Marks：

T+,T,Xn,F

GHS Classification：

|Danger|H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]|P260, P261, P262, P264, P270, P271, P280, P284, P301+P310, P302+P350, P302+P352, P304+P340, P305+P351+P338, P310, P312, P320, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 40 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

3,4-dihydroxy-15-acetoxy-8-(3-methylbutyryloxy)-12,13-epoxy-delta9-trichothecene

HT 2 Toxin Use and Manufacturing

HT-2 Toxin is a trichothecene group mycotoxin. HT-2 Toxin is the 4-hydroxy analogue of T-2 Toxin (T002980) which has been shown to induce DNA damage and cell death on prolonged administration.

Computed Properties

Molecular Weight:424.5
XLogP3:0.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:7
Exact Mass:424.20971797
Monoisotopic Mass:424.20971797
Topological Polar Surface Area:115
Heavy Atom Count:30
Complexity:777
Defined Atom Stereocenter Count:8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes