Disodium clodronate tetrahydrate
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Disodium clodronate tetrahydrate
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CAS No:
88416-50-6
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Formula:
CH4Cl2O6P2.4H2O.2Na
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Chemical Name:
Disodium clodronate tetrahydrate
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Synonyms:
Phosphonic acid,P,P′-(dichloromethylene)bis-,sodium salt,hydrate (1:2:4);Phosphonic acid,(dichloromethylene)bis-,disodium salt,tetrahydrate;Disodium clodronate tetrahydrate
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CAS No:
Description
Clodronate disodium tetrahydrate (Disodium clodronate tetrahydrate) is first-generation bisphosphonate, with anti-osteoporotic, anti-inflammatory and analgesic effects. Clodronate disodium tetrahydrate is a selective, potent, reversible and Cl- competitive vesicular nucleotide transporter (VNUT) inhibitor, with an IC50 of 15.6 nM. Clodronate disodium tetrahydrate inhibits vesicular ATP release from neurons and reduces chronic neuropathic and inflammatory pain[1][2].
Drug Function and Efficacy
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Registered Holders
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OLON S.P.A.
Active
Italy
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PATHEON AUSTRIA GMBH & CO. KG
Active
European Union
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ABIOGEN PHARMA S.P.A.
Active
European Union
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Disodium clodronate tetrahydrate
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