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Alprenolol hydrochloride

Alprenolol hydrochloride structure

CAS No:
13707-88-5
Formula:
C15H23NO2.ClH
Chemical Name:
Alprenolol hydrochloride
Synonyms:
2-Propanol,1-[(1-methylethyl)amino]-3-[2-(2-propen-1-yl)phenoxy]-,hydrochloride (1:1);2-Propanol,1-(o-allylphenoxy)-3-(isopropylamino)-,hydrochloride;2-Propanol,1-[(1-methylethyl)amino]-3-[2-(2-propenyl)phenoxy]-,hydrochloride;1-(o-Allylphenoxy)-3-(isopropylamino)-2-propanol hydrochloride;Alprenolol hydrochloride;H 56/28;1-(2-Allylphenoxy)-2-hydroxy-3-isopropylaminopropane hydrochloride;Gubernal;Aptine;Alfeprol;Aptin;Betaptin;Dimacor;Aptol Duriles;Apllobal;(±)-1-(o-Allylphenoxy)-3-isopropylamino-2-propanol hydrochloride;(±)-Alprenolol hydrochloride;dl-Alprenolol chloride;DL-1-(o-Allylphenoxy)-3-isopropylamino-2-propanol hydrochloride;Regletin;Applobal;Yobir;Aprobal;1-(2-Allylphenoxy)-3-(isopropylamino)propan-2-ol hydrochloride;[2-Hydroxy-3-[2-(prop-2-en-1-yl)phenoxy]propyl](propan-2-yl)amine hydrochloride;13678-97-2
Categories:
Analytical Chemistry > Standard

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Description

White or almost white, crystalline powder or colourless crystals.

One of the ADRENERGIC BETA-ANTAGONISTS used as an antihypertensive, anti-anginal, and anti-arrhythmic agent.

Alprenolol hydrochloride Basic Attributes

Molecular Weight：

285.81

Exact Mass：

285.149567

EC Number：

237-244-4

NSC Number：

759561

HScode：

2922509090

Characteristics

PSA：

41.5

XLogP3：

3.34570

Appearance：

off-white powder

Density：

1.007g/cm3

Melting Point：

107-109 °C

Boiling Point：

383.4ºC at 760 mmHg

Flash Point：

185.7ºC

Water Solubility：

H2O: 50 mg/mL

Storage Conditions：

2-8°C

Toxicity：

LD50 in mice, rats, rabbits (mg/kg): 278.0, 597.0, 337.3 orally (Marmo)

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

3249

wgk germany：

hazard class code：

RTECS Number：

UA5425000

Marks：

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 41 companies from 1 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here. (See all compounds classified as Sympatholytics.)|Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety. (See all compounds classified as Adrenergic beta-Antagonists.)|Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)

MeSH Entry Terms：

1-(o-Allylphenoxy)-3-(isopropylamino)-2-propanol

Alprenolol hydrochloride Use and Manufacturing

Methods of Manufacturing

Synthesized with the intermediate o-allyl glycidoxybenzene and sodium boron hydrogen, ammonia, acetone, hydrogen chloride as raw materials to obtain Xindeshu hydrochloride.

Uses

Alprenlol Hydrochloride acts as a β-adrenergic blocking agent against arrhythmia.

Computed Properties

Molecular Weight:285.81
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:8
Exact Mass:285.1495567
Monoisotopic Mass:285.1495567
Topological Polar Surface Area:41.5
Heavy Atom Count:19
Complexity:231
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes