 Home > Encyclopedia > Fluocortolone pivalate

Fluocortolone pivalate

Fluocortolone pivalate structure

CAS No:
29205-06-9
Formula:
C27H37FO5
Chemical Name:
Fluocortolone pivalate
Synonyms:
Pregna-1,4-diene-3,20-dione,21-(2,2-dimethyl-1-oxopropoxy)-6-fluoro-11-hydroxy-16-methyl-,(6α,11β,16α)-;Pregna-1,4-diene-3,20-dione,6α-fluoro-11β,21-dihydroxy-16α-methyl-,21-pivalate;(6α,11β,16α)-21-(2,2-Dimethyl-1-oxopropoxy)-6-fluoro-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione;Fluocortolone 21-trimethylacetate;Fluocortolone pivalate;Fluocortolone trimethylacetate;Flucortolone pivalate;6α-Fluoro-11β-hydroxy-21-trimethylacetoxy-16α-methylpregna-1,4-diene-3,20-dione
Categories:
Analytical Chemistry > Standard

Description

White or almost white, crystalline powder

Fluocortolone pivalate is a corticosteroid hormone.|A glucocorticoid with anti-inflammatory activity used topically for various skin disorders.

Fluocortolone pivalate Basic Attributes

Molecular Weight：

460.5780832

Exact Mass：

460.58

EC Number：

249-504-4

UNII：

9J8AL6K50Q

Characteristics

PSA：

80.7

XLogP3：

4.4

Density：

1.19±0.1 g/cm3(Predicted)

Melting Point：

187 °C

Boiling Point：

572.3ºC at 760mmHg

Flash Point：

299.9ºC

Refractive Index：

1.544

Safety Information

Precautionary statement(s)：

P201, P202, P260, P264, P270, P273, P281, P301+P312, P308+P313, P314, P330, P405, P501

Hazard Statements：

H302

GHS Classification：

|Danger|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P260, P264, P270, P273, P281, P301+P312, P308+P313, P314, P330, P405, and P501|Aggregated GHS information provided by 24 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)|A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system. (See all compounds classified as Glucocorticoids.)

MeSH Entry Terms：

Caproate, Fluocortolone

Fluocortolone pivalate Use and Manufacturing

Fluocortolone Pivalate is a glucocorticoid.

Computed Properties

Molecular Weight:460.6
XLogP3:4.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:460.26250244
Monoisotopic Mass:460.26250244
Topological Polar Surface Area:80.7
Heavy Atom Count:33
Complexity:929
Defined Atom Stereocenter Count:9
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes