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Ophiopogonin D

Ophiopogonin D structure

CAS No:
945619-74-9
Formula:
C44H70O16
Chemical Name:
Ophiopogonin D
Synonyms:
β-D-Galactopyranoside,(1β,3β,25R)-3-hydroxyspirost-5-en-1-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-xylopyranosyl-(1→3)]-6-deoxy-;(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-xylopyranosyl-(1→3)]-6-deoxy-β-D-galactopyranoside;Ophiopogonin D;Deacetylophiopogonin C;OJV-V;25(R)-Ruscogenin 1-O-[α-L-rhamnopyranosyl-(1→2)][β-D-xylopyranosyl-(1→3)]-β-D-fucopyranoside;11054-29-8;11088-12-3;41753-55-3;1868133-32-7
Categories:
Analytical Chemistry > Standard

Description

Ophiopogonin D, isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C29 steroidal glycoside[1]. Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca2+ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D has been used to treat inflammatory and cardi

Ophiopogonin D is a steroid saponin.

Ophiopogonin D Basic Attributes

Molecular Weight：

855.017

Exact Mass：

855.02

Characteristics

PSA：

236

XLogP3：

5.54

Density：

1.4±0.1 g/cm3

Melting Point：

263-265 °C

Refractive Index：

1.617

Safety Information

Transport codes：

NONH for all modes of transport

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

Drug Information

MeSH Entry Terms：

ophiopogonin D

Computed Properties

Molecular Weight:855.0
XLogP3:1
Hydrogen Bond Donor Count:8
Hydrogen Bond Acceptor Count:16
Rotatable Bond Count:6
Exact Mass:854.46638614
Monoisotopic Mass:854.46638614
Topological Polar Surface Area:236
Heavy Atom Count:60
Complexity:1590
Defined Atom Stereocenter Count:26
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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