Milnacipran hydrochloride
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Milnacipran hydrochloride
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CAS No:
101152-94-7
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Formula:
C15H22N2O.ClH
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Chemical Name:
Milnacipran hydrochloride
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Synonyms:
Cyclopropanecarboxamide,2-(aminomethyl)-N,N-diethyl-1-phenyl-,hydrochloride (1:1),(1R,2S)-rel-;Cyclopropanecarboxamide,2-(aminomethyl)-N,N-diethyl-1-phenyl-,monohydrochloride,cis-(±)-;Cyclopropanecarboxamide,2-(aminomethyl)-N,N-diethyl-1-phenyl-,monohydrochloride,(1R,2S)-rel-;F 2207;Milnacipran hydrochloride;Cyclopropanecarboxamide,2-(aminomethyl)-N,N-diethyl-1-phenyl-,monohydrochloride,cis-;Ixel;Dalcipran;Toledomin;Savella;Tivanyl;Joncia;86181-08-0
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CAS No:
Description
Crystalline Solid
Levomilnacipran is a serotonin and norepinephrine reuptake inhibitor used to treat major depressive disorders. Levomilnacipran is an enantiomer of milnacipran, which is used to treat fibromyalgia. Levomilnacipran and milnacipran have been associated with a low rate of transient elevations in serum aminotransferase levels during treatment and with rare instances of clinically apparent acute liver injury with jaundice.|A cyclopropanecarboxamide serotonin and norepinephrine reuptake inhibitor (SNRI) that is used in the treatment of FIBROMYALGIA.
Milnacipran hydrochloride Basic Attributes
282.81
282.149902
200-659-6
759806
DTXSID4046785
29242990
Characteristics
48 Ų
white solid
181-189 °C
421.5°C at 760 mmHg
9℃
H2O: 19 mg/mL
2-8°C
LD50 orally in mice: 237 mg/kg (Bonnaud)
Safety Information
III
6.1
UN 2811 6.1/PG 3
3
22-39/23/24/25-23/24/25-11
7-16-36/37-45
GZ1014010
Xn,T,F
P301 + P310
H301
|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 49 companies from 5 notifications to the ECHA C&L Inventory.
Toxicity
In large clinical trials, elevations in serum aminotransferase levels during levomilnacipran and milnacipran therapy occurred in 7% of patients, but were usually mild and self-limited. Elevations above 5 times the upper limit of normal (ULN) occurred in ~1% of patients and generally resolved, even without dose adjustment or discontinuation. There has been a single published report of clinically apparent liver injury with jaundice attributed to milnacipran therapy, with a mixed pattern of liver enzyme elevations, transient increases in bilirubin without jaundice, immunoallergic features and rapid recovery on stopping (Case 1).
Drug Information
Levomilnacipran is a serotonin and norepinephrine reuptake inhibitor used to treat major depressive disorders. Levomilnacipran is an enantiomer of milnacipran, which is used to treat fibromyalgia. Levomilnacipran and milnacipran have been associated with a low rate of transient elevations in serum aminotransferase levels during treatment and with rare instances of clinically apparent acute liver injury with jaundice.
Antidepressants
A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS. (See all compounds classified as Analgesics, Non-Narcotic.)|Drugs that selectively block or suppress the plasma membrane transport of SEROTONIN and NORADRENALINE into axon terminals and are used as ANTIDEPRESSIVE AGENTS. (See all compounds classified as Serotonin and Noradrenaline Reuptake Inhibitors.)
1 Phenyl 1 diethylaminocarbonyl 2 aminomethylcyclopropane HCl
Milnacipran hydrochloride Use and Manufacturing
antibacterial
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:282.81
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:282.1498911
Monoisotopic Mass:282.1498911
Topological Polar Surface Area:46.3
Heavy Atom Count:19
Complexity:295
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Drug Function and Efficacy
No specific mention from the above information
Registered Holders
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Luzhou Kereide Pharmaceutical Co., Ltd.
Active![China]()
China
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CENTAUR PHARMACEUTICALS PVT LTD
Active![United States]()
United States
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LUPIN MANUFACTURING SOLUTIONS LTD
Active![United States]()
United States
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