4-ETHOXY-3-FLUOROPHENYLBORONIC ACID

The compound (T-26) (43.8 g) was dissolved in DryTHF (400 ml), and the resultant solution was cooled to -70°C. In a nitrogen atmosphere, n-BuLi (133 ml) was added dropwise, and agitation was carried out at -70°C for 2 hours. Then, a DryTHF solution of trimethyl borate (64.8 g) was slowly added dropwise at -70°C, and the resultant solution was heated to room temperature and agitated for 16 hours. After completion of the reaction, 2N-HCl (200 ml) was added, and then extraction was carried out with toluene, an organic layer was washed with water and a saturated aqueous solution of sodium chloride, and then the resultant solution was dried over anhydrous magnesium sulfate and concentrated under reduced pressure, and thus a light brown solid was obtained. The resultant material was subjected to recrystallization (heptane:toluene = 4:1 in a volume ratio), (T-27) was obtained as a colorless crystal (23.9 g, yield: 65percent).

suzuki reaction

Molecular Weight:183.97
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:184.0707025
Monoisotopic Mass:184.0707025
Topological Polar Surface Area:49.7
Heavy Atom Count:13
Complexity:156
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes