Glycyl-L-valine

white fine crystalline powderChEBI: A dipeptide formed from glycine and L-valine residues.

Solid

Gly-Val is a dipeptide formed from glycine and L-valine residues. It has a role as a human metabolite.

(Sequence III) represents a hydroxyl group (-OH) or any of the following amino acid sequences: ... Gly Val Pro Gly (SEQ ID NO: 71) Gly Val Pro Gly Val Glysequence III represents a hydroxyl group (-OH) or any of the following amino acid sequences: ... Gly Val Pro Gly Asp Gly (SEQ ID NO: 69) Gly Val Pro Gly Asp (SEQ ID NO: 70) Gly Val Pro Gly (SEQ ID NO: 71) Gly Val Pro Gly Val Gly.A preferred amino acid sequence to be added to the C-terminus may be selected from the following sequences (1) to (15); ... (10) Gly Val Pro Gly Asp Gly, (11) Gly Val Pro Gly Asp, (12) Gly Val Pro Gly, (13) Gly Val Pro, (14) Gly Val, and (15) Gly.and wherein said polypeptide optionally still further consists of a carboxy-terminal peptide selected from the group consisting of; ... Gly-Val-Pro-Gly-Asp-Gly-Asp, Gly-Val-Pro-Gly-Asp-Gly, Gly-Val-Pro-Gly-Asp, Gly-Val-Pro-Gly, Gly-Val-Pro, Gly-Val, and Gly.A preferred amino acid sequence to be added to the C-terminus may be selected from the following sequences (1) to (15); ... (12) Gly Val Pro Gly, (13) Gly Val Pro, (14) Gly Val, and (15) Gly.The polypeptide of claim 3, further having a carboxy-terminal polypeptide having an amino acid sequence selected from the group consisting of: ... Gly-Val-Pro-Gly-Asp-Gly-Asp, Gly-Val-Pro-Gly-Asp-Gly, Gly-Val-Pro-Gly-Asp, Gly-Val-Pro-Gly, Gly-Val-Pro, Gly-Val, and Gly.The polypeptide of claim 1, further having a carboxy-terminal polypeptide having an amino acid sequence selected from the group consisting of: ... Gly-Val-Pro-Gly-Asp-Gly-Asp, Gly-Val-Pro-Gly-Asp-Gly, Gly-Val-Pro-Gly-Asp, Gly-Val-Pro-Gly, Gly-Val-Pro, Gly-Val, and Gly.General procedure: Heteroleptic Cu-dipeptide-necuproine complexes where L-dipeptide: Gly-Val, Gly-Leu, Gly-Phe, Ala-Gly, Ala-Phe, Val-Phe, Phe-Ala or Phe-Phe were obtained as follows (Fig. 1). 0.1mmol of dipeptide were dissolved in the minimum volume of warm water (10-50mL) and 0.1mmol of CuSO4·5H2O was added. The pH was adjusted to 7 with a 0.1M NaOH solution. A solution of 0.1mmol of neo in 5mL of ethanol was added, while stirring. The compounds were isolated by evaporation at 40-50C, until blue crystals were formed. Yield 60-70%. Crystals suitable for X-ray analysis were obtained by slow evaporation of solvent at room temperature.

Molecular Weight:174.20
XLogP3:-2.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:174.10044231
Monoisotopic Mass:174.10044231
Topological Polar Surface Area:92.4
Heavy Atom Count:12
Complexity:180
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes