KRN 633
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KRN 633
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CAS No:
286370-15-8
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Formula:
C20H21ClN4O4
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Chemical Name:
KRN 633
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Synonyms:
KRN 633;N-[2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-propylurea;1-(2-chloro-4-(6,7-diMethoxyquinazolin-4-yloxy)phenyl)-3-propylurea;N-[2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-propylureaKRN633;VEGFR Tyrosine Kinase Inhibitor III, KRN633
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CAS No:
Description
KRN-633 is a potent VEGFR inhibitor with IC50s of 170, 160 and 125 nM for VEGFR1, VEGFR2 and VEGFR3, respectively.
Characteristics
94.6
3.9
white to beige
1.3±0.1 g/cm3
545.6±50.0°C at 760 mmHg
283.7±30.1 °C
1.629
DMSO: soluble3mg/mL, clear (warmed)
-20°C
KRN 633 Use and Manufacturing
KRN 633 is an ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 170 nM/160 nM/125 nM and also inhibits PDGFRα/β with IC50 of 965 nM/9850 nM.
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