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KRN 633

KRN 633 structure

CAS No:
286370-15-8
Formula:
C20H21ClN4O4
Chemical Name:
KRN 633
Synonyms:
KRN 633;N-[2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-propylurea;1-(2-chloro-4-(6,7-diMethoxyquinazolin-4-yloxy)phenyl)-3-propylurea;N-[2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-propylureaKRN633;VEGFR Tyrosine Kinase Inhibitor III, KRN633
Categories:
Biochemical Engineering > Inhibitors

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Description

KRN-633 is a potent VEGFR inhibitor with IC50s of 170, 160 and 125 nM for VEGFR1, VEGFR2 and VEGFR3, respectively.

KRN 633 Basic Attributes

Molecular Weight：

416.85814

Exact Mass：

416.125122

Characteristics

PSA：

94.6

XLogP3：

3.9

Appearance：

white to beige

Density：

1.3±0.1 g/cm3

Boiling Point：

545.6±50.0°C at 760 mmHg

Flash Point：

283.7±30.1 °C

Refractive Index：

1.629

Water Solubility：

DMSO: soluble3mg/mL, clear (warmed)

Storage Conditions：

-20°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

Marks：

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

KRN 633 Use and Manufacturing

KRN 633 is an ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 170 nM/160 nM/125 nM and also inhibits PDGFRα/β with IC50 of 965 nM/9850 nM.

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KRN 633

CAS No.: 286370-15-8

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Guide of KRN 633

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Recommended Suppliers
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KRN 633

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