4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE
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4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE
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CAS No:
327036-89-5
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Formula:
C10H10N2O2S1
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Chemical Name:
4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE
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Synonyms:
GSK-3InhibitorI,TDZD-8;NP 01139;1,2,4-Thiadiazolidine-3,5-dione,2-Methyl-4-(phenylMethyl)-;TDZD-8/TDZD8;4-Benzyl-2-methyl-[1,2,4]thiadiazolidine-3,5-dione TDZD-8;TDZD-8, >=98%
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CAS No:
Description
TDZD-8 is an inhibitor of GSK-3β, with an IC50 of 2 μM; TDZD-8 shows less potent activities against Cdk-1/cyclin B, CK-II, PKA, and PKC, with all IC50s of >100 μM.
TDZD-8 is a member of the class of thiadiazolidines that is 1,2,4-thiadiazolidine-3,5-dione which is substituted by a methyl group at position 2 and by a benzyl group at position 4. It is a non-ATP competitive inhibitor of glycogen synthase kinase 3beta (GSK3beta). An experimental compound which was being developed for the potential treatment of Alzheimer's disease. It has a role as an EC 2.7.11.26 (tau-protein kinase) inhibitor, an apoptosis inducer, an antineoplastic agent, a neuroprotective agent and an anti-inflammatory agent. It is a thiadiazolidine and a member of benzenes.
4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE Basic Attributes
222.26
222.046295
DTXSID30399590
2934999090
Characteristics
65.9
1.5
white needles
1.4±0.1 g/cm3
63-64.4 °C
335.5°C at 760 mmHg
156.7±25.9 °C
1.646
DMSO: 18 mg/mL
2-8°C
Safety Information
NONH for all modes of transport
3
43
36/37
Xi
P261-P342 + P311
H334
|Danger|H334 (97.44%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]|P261, P285, P304+P341, P342+P311, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory.
4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE Use and Manufacturing
Glycogen Synthase Kinase-3? is a highly conserved ubiquitously expressed serine/threonine protein kinase involved in signal transduction cascades of multiple cellular processes.TDZD-8 is a thiadiazolidinone (TDZD) analogue that acts as a highly selectiv
Computed Properties
Molecular Weight:222.27
XLogP3:1.5
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:222.04629874
Monoisotopic Mass:222.04629874
Topological Polar Surface Area:65.9
Heavy Atom Count:15
Complexity:277
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE
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