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(-)-Nutlin 3

(-)-Nutlin 3 structure

CAS No:
675576-98-4
Formula:
C30H30Cl2N4O4
Chemical Name:
(-)-Nutlin 3
Synonyms:
2-Piperazinone,4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-;Piperazinone,4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-;4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone;4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazol-1-yl]carbonyl]piperazin-2-one;Nutlin 3a;(-)-Nutlin 3;SML 0580;4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone
Categories:
Biochemical Engineering > Inhibitors

Description

Nutlin 3a is an active enantiomer of Nutlin-3, acts as a murine double minute (MDM2) antagonist that inhibits MDM2-p53 interactions and stabilizes the p53 protein, and thereby induces cell cycle arrest and apoptosis.

(-)-Nutlin 3 Basic Attributes

Molecular Weight：

581.497

Exact Mass：

581.49

Characteristics

PSA：

83.5

XLogP3：

5.2

Appearance：

white to beige

Density：

1.4±0.1 g/cm3

Refractive Index：

1.648

Water Solubility：

DMSO: soluble5mg/mL, clear

Storage Conditions：

-20°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

Marks：

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

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Nutlin 3a

CAS No.: 675576-98-4

Content: 99.00%

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