3-Hydroxyazetidine hydrochloride
-
3-Hydroxyazetidine hydrochloride
structure -
-
CAS No:
18621-18-6
-
Formula:
C3H7NO.ClH
-
Chemical Name:
3-Hydroxyazetidine hydrochloride
-
Synonyms:
3-Azetidinol,hydrochloride (1:1);3-Azetidinol,hydrochloride;3-Hydroxyazetidine hydrochloride;Azetidine-3-ol hydrochloride;Azetidin-3-ol hydrochloride;3-Hydroxyazetedine hydrochloride
- Categories:
-
CAS No:
3-Hydroxyazetidine hydrochloride Basic Attributes
109.55
109.029442
1592732-453-0
DTXSID30374721
29339900
Characteristics
32.3
0.08130
White Solid
91-92 °C
170.7°C at 760 mmHg
120.4ºC
Soluble in water, DMSO, methanol.
Room temperature.
0.464mmHg at 25°C
Safety Information
IRRITANT
NONH for all modes of transport
3
36/37/38-41-37/38-22
26-36/37/39
C,Xi,Xn
Harmful/Corrosive
P261-P280-P305 + P351 + P338
H302-H315-H318-H335
|Danger|H302 (85.71%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 50 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
3-Hydroxyazetidine hydrochloride Use and Manufacturing
A solution of l-(diphenylmethyl)-3-hydroxyazetidine hydrochloride (11.8 g) in absolute ethanol (700 mL) was hydrogenated at room temperature over Pd(OH)2/C in a Parr shaker at 4 atm. After 12 hr the catalyst was filtered off and the filtrate evaporated to dryness to give3-hydroxyazetidine hydrochloride (4.20 g, 94percent). A reaction mixture of N-benzhydrylazetidin-3-ol HCl salt (2.76 g, 10.0 mmol) with palladium hydroxide, 20percent Pd (dry base) on C (400 mg) in 50 mL of MeOH was hydrogenated at 55 psi for 48 h. The reaction mixture was filtered through Celite pad and washed well with MeOH. The filtrate was concentrated under vacuum at room temperature water bath. The residue was treated with ether (3x30 ml) and the solvent is decanted. The solid was air dried to give 571 mg of HCl salt product (2) as white solid (52percent yield). 1H NMR (400 MHz, DMSO-D6) δ ppm 3.33 (s, 1H) 3.63-3.80 (m, 2H) 3.93-4.09 (m, 2H) 4.40-4.58 (m, 1H) 6.18 (d, J=6.32 Hz, 1H).A reaction mixture of N-benzhydrylazetidin-3-ol HCI salt (2.76 g, 10.0 mmol) with palladium hydroxide, 20percent Pd (dry base) on C (400 mg) in 50 mL of MeOH was hydrogenated at 55 psi for 48 h. The reaction mixture was filtered through Celite pad and washed well with MeOH. The filtrate was concentrated under vacuum at room temperature water bath. The residue was treated with ether (3x30ml) and the solvent is decanted. The solid was air dried to give 571 mg of HCI salt product (2-2) as white solid (52percent yield). To a soln of 1-benzhydrylazetan-3-ol (1.0 g, 4.16 mmol) in methanol (20 mL) were added 10percent Pd/C (1.0 g) and 4N HCl in 1, 4-dioxane (2 mL). The mixture was flushed with Ar, and then stirred on Parr apparatus at 40 psi H2 for 6 h at 60°. The mixture was cooled to room temperature and filtered through celite. The filtrate was concentrated and the resulting solid was washed with diethyl ether to give the desired product 0.31 g (68percent). 1H NMR (MeOD-d4): δ 4.17 (m, 1H), 4.22 (m, 2H), 3.91 (m, 2H)
A useful intermediate in the synthesis of polypeptides
Computed Properties
Molecular Weight:109.55
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:2
Exact Mass:109.0294416
Monoisotopic Mass:109.0294416
Topological Polar Surface Area:32.3
Heavy Atom Count:6
Complexity:33.9
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Recommended Suppliers of 3-Hydroxyazetidine hydrochloride
-
![China]()
CN
4 YRS
Business licensed Certified factoryManufactory Supplier of Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst,Chemical Materials,Chem&Pharm Intermediates,Organic Intermediates,Feed AdditiveInquiryCAS No.: 18621-18-6Grade: Pharmaceutical GradeContent: 99% -
![China]()
CN
5 YRS
Business licensedTrader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives -
![China]()
CN
4 YRS
Business licensedTrader Supplier of semaglutideInquiryCAS No.: 18621-18-6Content: 99% -
![China]()
CN
5 YRS
Business licensedTrader Supplier of PVC resin,pvc paste resin,melamineInquiryCAS No.: 18621-18-6Grade: Industrial GradeContent: 99% -
![China]()
CN
3 YRS
Business licensed Certified factoryManufactory Supplier of Dyes,Textile agent,Medical intermediate,API,Pigments,Basic ChemicalsInquiryCAS No.: 18621-18-6Grade: pharmaceutical gradeContent: 99%
Learn More Other Chemicals
-
4H-1-Benzopyran-4-one, 2-[4-[3-(dibutylamino)propoxy]-3,5-dimethylbenzoyl]-, hydrochloride (1:1)
67652-33-9
-
Cyclopropanecarboxylic acid, 1-amino-2-ethenyl-, ethyl ester, hydrochloride (9CI)
681807-60-3
-
CYCLOPENTYL-(3,4,5-TRIMETHOXY-BENZYL)-AMINE HYDROCHLORIDE
1052525-88-8
-
2-Cyclopropylbenzenemethanamine hydrochloride Formula
118184-64-8
-
Des[4-(2-cycloproylMethoxy)] Betaxolol Hydrochloride Formula
464877-45-0
-
Ethanamine, 2-(decylthio)-, hydrochloride (1:1) Formula
36362-09-1
-
4,7-Dichloro-2-propylquinoline hydrochloride Structure
1204812-22-5
-
6,7-Dichloro-4-hydrazino-2-methylquinoline hydrochloride Structure
1170377-12-4
-
What is 2,8-Diazaspiro[4.5]decan-1-one, 2-[(4-bromophenyl)methyl]-, hydrochloride (1:1)
832710-56-2
-
What is 6,7-Dichloro-4-hydrazinoquinoline hydrochloride
1171843-02-9
3-Hydroxyazetidine hydrochloride
SDSRequest for Quotation