7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid
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7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid
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CAS No:
100361-18-0
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Formula:
C12H8ClFN2O3
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Chemical Name:
7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid
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Synonyms:
1,8-Naphthyridine-3-carboxylic acid,7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-;7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid;3-Carboxy-7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro[1,8]naphthyridine;7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid;1-Cyclopropyl-6-fluoro-7-chloro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylicacid;118688-40-7
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CAS No:
7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid Basic Attributes
282.65
282.65
1312995-182-4
DTXSID10453583
2933990090
Characteristics
70.5
3.4
White powder
1.727±0.06 g/cm3(Predicted)
209-212 °C
485.9±45.0 °C(Predicted)
247.7±28.7 °C
1.692
0mmHg at 25°C
7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid Use and Manufacturing
To a solution of ethyl 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1, 4-dihydro-1, 8-naphtyridine-3-carboxylate (0.1g, 0.32 mmol) in THF (5 ml) was added conc.HCl (45 μL, 0.7 mmol). The reaction mixture was heated to reflux for 2 h. After completion of the reaction by TLC, reaction mixture was cooled to room temperature. The solid precipitated was filtered to give the title compound as a solid (70 mg, 78percent).
Gemifloxacin intermediate as antibacterial agent
Computed Properties
Molecular Weight:282.65
XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:282.0207480
Monoisotopic Mass:282.0207480
Topological Polar Surface Area:70.5
Heavy Atom Count:19
Complexity:466
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid
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