ETHYL 2-CHLORO-4-METHYLPYRIMIDINE-5-CARBOXYLATE

White solid

General procedure: A solution of compound 2 (10 mmol) in phosphorous oxychloride (10 mL) was heated under reflux for 30 min. The resulting reaction mixture was distilled under reduced pressure to remove excess phosphorous oxychloride. Last traces of phosphorous oxychloride were removed by azeotrophic distillation with dry benzene and crude product was purified by column chromatography to afford pure product 3.To a solution of ethyl 6-methyl-2-oxo-1 2-dihydropyrimidine-5-carboxylate (62 g 340 mmol) stirred under N2 at 20 was added POCl3 (496 g 3233 mmol) slowly. The reaction mixture was stirred at 80 for 12 h. Then the solution was concentrated and distributed between EA and saturated NaHCO3 solution. The combined organic extract was washed with brine dried over Na2SO4 filtered and concentrated. The residue was purified by silica column chromatography (PE/EA 101) . All fractions found to contain product by TLC (PE/EA 101 Rf 0.7) were combined and concentrated to yield a yellow solid of ethyl 2-chloro-4-methylpyrimidine-5-carboxylate (9 g 44.9 mmol 13.18yield) 1H NMR (400 MHz CDCl3) δ 9.01 (s 1H) 4.41 (q J 7.2 Hz 2H) 2.82 (s 3H) 1.41 (t J 7.2 Hz 3H) .A mixture of POCI

Molecular Weight:200.62
XLogP3:1.8
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:200.0352552
Monoisotopic Mass:200.0352552
Topological Polar Surface Area:52.1
Heavy Atom Count:13
Complexity:189
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes