AcetaMide, N-1H-pyrrolo[2,3-c]pyridin-5-yl-

Step c: Synthesis of N-(1H-pyrrolo[2, 3-c]pyridin-5-yl)acetamideTo a solution of A/-{4-[( )-2-(dimethylamino)ethenyl]-5-nitropyhdin-2- yl}acetamide (0.7g, 3 mmol, Step b) in methanol and dichloromethane (5:1 , 120 mL), palladium on carbon (0.4 g) was added followed by addition of acetic acid (7 mL). The reaction mixture was then purged with hydrogen gas and stirred overnight at room temperature. The resulting mixture was filtered over celite bed, and the residue was washed with methanol (100 mL). The combined filtrate was concentrated under vacuum and purified by silica gel column chromatography using methanol in dichloromethane (2percent) to afford /V-(1 H-pyrrolo[2, 3-c]pyridin-5-yl)acetamide (0.35 g, 71 percent).To a solution of N-{4-[(Z)-2-(dimethylamino)ethenyl]-5-nitropyridin-2-yl}acetamide (0.7 g, 3 mmol, Step b) in methanol and dichloromethane (5:1, 120 mL), palladium on carbon (0.4 g) was added followed by addition of acetic acid (7 mL). The reaction mixture was then purged with hydrogen gas and stirred overnight at room temperature. The resulting mixture was filtered over celite bed, and the residue was washed with methanol (100 mL). The combined filtrate was concentrated under vacuum and purified by silica gel column chromatography using methanol in dichloromethane (2percent) to afford N-(1H-pyrrolo[2, 3-c]pyridin-5-yl)acetamide (0.35 g, 71percent).

Molecular Weight:175.19
XLogP3:0.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:175.074561919
Monoisotopic Mass:175.074561919
Topological Polar Surface Area:57.8
Heavy Atom Count:13
Complexity:207
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes