3-Amino-6-chloro-2-picoline
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3-Amino-6-chloro-2-picoline
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CAS No:
164666-68-6
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Formula:
C6H7ClN2
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Chemical Name:
3-Amino-6-chloro-2-picoline
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Synonyms:
TIMTEC-BB SBB010194;3-AMINO-2-CHLORO-4-PICOLINE;3-AMINO-2-CHLORO-4-METHYLPYRIDINE;3-AMINO-6-CHLORO-2-METHYLPYRIDINE;3-AMINO-6-CHLORO-2-PICOLINE;5-AMINO-2-CHLORO-6-PICOLINE;6-CHLORO-2-METHYL-PYRIDIN-3-YLAMINE;2-CHLORO-4-METHYLPYRIDIN-3-AMINE
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CAS No:
Characteristics
38.9
1.5
Pale yellow Solid
1.2124 (rough estimate)
93-94℃
232.49°C (rough estimate)
126.7±25.9 °C
1.4877 (estimate)
0.00272mmHg at 25°C
Safety Information
IRRITANT, TOXIC
2811
22-37/38-41-20/21/22
26-39-36/37-24/25
Xi,T,Xn
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
H315
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
3-Amino-6-chloro-2-picoline Use and Manufacturing
Step 1: 6-Chloro-2-methylpyridin-3-amine (44). To a stirred solution of 43 (5 g, 29 mmol) in EtOH (20 mL) and cone. HCI (20 mL) was added Fe powder (16.2 g, 289 mmole) in small portions at RT over 30 min. Stirring was continued at RT for another 30 min. The solvent was distilled off under reduced pressure. Water was added and the resulting mixture was neutralized with NaHC0To a stirred solution of 55 (5 g, 29 mmol) in EtOH (20 mL) and cone HC1 (20 mL) was added Fe powder (16.2 g, 289 mmole) in small portions at RT over 30 min. The resulting reaction mixture was stirred at RT for an additional 30 min. The solvent was removed in vacuo and water was added to the residue which was then neutralized with NaHC0l, T-Thiocarbonyldiimidazole (516 mg, 2.75 mmol, 95 mass%) and then hydrochloric acid in dioxane (1.25 mL, 5.00 mmol, 4 mol/L) were added to a solution of Step 1: Acetic acid 6-chloro-2-methyl-pyridin-3-yl ester; A mixture of boron trifluoride etherate (667 muL, 5.3 mmol) and 1, 2-dimethoxyethane (2 mL) was cooled to -15 C. in an ice/acetonitrile bath and stirred at this temperature for 15 min under nitrogen. A solution of Step 1: water (25 mL), boric acid (434 mg, 7.01 mmol) and glycerol (10-15 drops) were added to a stirred solution of
Computed Properties
Molecular Weight:142.58
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:142.0297759
Monoisotopic Mass:142.0297759
Topological Polar Surface Area:38.9
Heavy Atom Count:9
Complexity:97.1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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