Bindarit
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Bindarit
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CAS No:
130641-38-2
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Formula:
C19H20N2O3
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Chemical Name:
Bindarit
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Synonyms:
Bindarit;Propanoic acid, 2-Methyl-2-[[1-(phenylMethyl)-1H-indazol-3-yl]Methoxy]-;2-[(1-Benzyl-1H-indazol-3-yl)methoxy]-2-methylpropionic acid;AF 2838;2-((1-Benzyl-1H-indazol-3-yl)Methoxy)-2-Methylpropanoic acid
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CAS No:
Description
Bindarit(AF-2838), a CCL2, CCL7 and CCL8 inhibitor, is an anti-inflammatory agent.Target: OthersBindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8. Oral administration of Bindarit at 50 mg/kg in NZB/W mice delays the onset of proteinuria, significantly protects from renal function impairment, and prolongs survival of NZB/W mice or lupus mice. Bindarit treatment completely MCP-1 up-regulation during the progression of nephrit
Bindarit has been used in trials studying the prevention and treatment of Coronary Restenosis and Diabetic Nephropathy.
Drug Information
Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins. (See all compounds classified as Protein Synthesis Inhibitors.)|Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)
2-((-1-benzyl-indazol-3-yl)methoxy)-2-methylpropionic acid
Bindarit Use and Manufacturing
Bindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.
Computed Properties
Molecular Weight:324.4
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:324.14739250
Monoisotopic Mass:324.14739250
Topological Polar Surface Area:64.4
Heavy Atom Count:24
Complexity:434
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
