4-broMo-5-Methylbenzene-1,2-diaMine

4.OO g (17.312 mmol) of the compound from example 38A was dissolved in 100 ml ethanol and 15.63 g (69.248 mmol) of tin(II) chloride dihydrate was added. The mixture was stirred overnight at 70°C. After cooling, water was added, it was made weakly alkaline with saturated aqueous sodium hydrogen carbonate solution and extracted three times with ethyl acetate. The combined organic phases were dried over sodium sulfate and concentrated in a rotary evaporator at reduced pressure. The residue was dried under high vacuum. We obtained 3.23 g (89percent of theor.) of the target compound.LC-MS (method 1): R, = 1.07 min; MS (EIpos): m/z = 201 [M+H]Example 24; 3-[3-(1, 4-Diethyl-7-methyl-2, 3-dioxo-1, 2, 3, 4-tetrahydro-quinoxalin-6-yl)-4-trifluoromethoxy-phenyl]-acrylic acid (Compound 24); A. 4-Bromo-5-methyl-benzene-1, 2-diamine (Compound 24A); To the solution of 4-methyl-2-nitro-phenylamine (1 g, 1 eq.) in 15 mL of acetic acid was added NBS (1.4 , 1.2 eq.). The reaction was allowed to stir for 2.5 hours. Reaction was then diluted with 15 mL of water and Zn dust (1.29 g, 3 eq.) was added. Reaction was stirred for 1 hour, filtered and then pH was adjusted to 7 with ammonia. The aqueous layer was extracted with CH

Molecular Weight:201.06
XLogP3:1.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Exact Mass:199.99491
Monoisotopic Mass:199.99491
Topological Polar Surface Area:52
Heavy Atom Count:10
Complexity:118
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes