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Home > Encyclopedia > 7-BroMo-iMidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester

7-BroMo-iMidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester

7-BroMo-iMidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester structure

7-BroMo-iMidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester 

structure
  • CAS No:

    1134327-98-2

  • Formula:

    C10H9BrN2O2

  • Chemical Name:

    7-BroMo-iMidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester

  • Synonyms:

    Ethyl 7-bromoimidazo[1,2-a]pyridine-3-carboxylate;7-Bromo-imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester;Ethyl7-Bromoimidazo[1,2-a]pyridine-3-carboxylate;SCHEMBL2051512;CTK8C4546;DTXSID70736703;Imidazo[1,2-a]pyridine-3-carboxylic acid, 7-bromo-, ethyl ester;ANW-72322;MFCD09994702;MFCD11045695

7-BroMo-iMidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester Basic Attributes

269.09466

267.984741

DTXSID70736703

2933990090

Characteristics

43.6

3

1.60±0.1 g/cm3(Predicted)

1.637

7-BroMo-iMidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester Use and Manufacturing

To a solution of sulfuric acid (4.54 g, 46.24 mmol, 2.46 mL, 1.6 eq) and ethanol (75 mL) at 0 °C was added Example 102A (16.90 g, 89.59 mmol, 3.1 eq) and 2-amino-4- bromopyridine (5.00 g, 28.90 mmol, 1 eq). The reaction was stirred at 80 °C for 5 hr. The reaction was cooled to 25 °C and was diluted with water. The aqueous solution was adjusted to pH=7, and extracted with ethyl acetate (300 mL*3). The combined organic phase was washed with brine (200 mL*2), dried with anhydrous sodium sulfate, filtered and concentrated in vacuo. The residue was purified by silica gel chromatography. Example 102B (1.70 g, 6.32 mmol, yield =22percent) was obtained as a white solid. (0193) [0114] MR: (CDCb, 400MHz): ppm 9.19 (d, J=7.2 Hz, 1H), 8.27 (s, 1H), 7.93 (s, 1H), 7.16 (dd, J=1.6, 7.6 Hz, 1H), 4.43 (q, J=7.6 Hz, 2H), 1.43 (t, J=7.2 Hz, 3H).

Computed Properties

Molecular Weight:269.09
XLogP3:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:267.98474
Monoisotopic Mass:267.98474
Topological Polar Surface Area:43.6
Heavy Atom Count:15
Complexity:250
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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