5'-broMo-1'-phenyl-[2,3'-bipyridin]-6'(1'H)-one

240 ml of dimethyl formamide 10.0 gm of 5'-bromo- -phenyl-[2, 3'-bipyridin]- 6'-(l'H)-one, 9.165 gm of 2-formyl phenyl boronic acid and 19.9 gm of cesium carbonate were charged in to a RBF. To the resulting reaction mixture Palladium (II) Acetate (0.171 gm) and triphenyl phosphine (0.8 gm) were added, reaction mixture was heated to 110 to 120C. After completion of reaction, the reaction mixture was filtered and the filtrate was cooled to precipitate the solid. The solid was dried under vacuum at below 70C for 12 hrs to give 8.0 gm of title compound.In a 500 mL round bottom flask, equipped with a mechanical stirrer, thermometer and an addition funnel, a solution of 18.75 g 3-bromo-5-(2-pyridyl)-1, 2-dihydropyridin-2-one in 300 mL methylene dichloride, 18.36 g 1-phenyl boronic acid, 3.47 g palladium triphenylphosphine and 10 mL triethyl amine were added and the reaction mixture was stirred for 1 hour at 25-35 C. The reaction mixture was filtered and the filtrate was evaporated to dryness. The residue was crystallised from ethyl acetate to obtain the title compound.

Molecular Weight:327.17
XLogP3:3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:326.00548
Monoisotopic Mass:326.00548
Topological Polar Surface Area:33.2
Heavy Atom Count:20
Complexity:438
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes