BOC-GLU(OBZL)-OME
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BOC-GLU(OBZL)-OME
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CAS No:
59279-58-2
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Formula:
C18H25NO6
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Chemical Name:
BOC-GLU(OBZL)-OME
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Synonyms:
BOC-GLU(OBZL)-OME;BOC-L-GLUTAMIC ACID GAMMA-BENZYL ESTER ALPHA-METHYL ESTER;BOC-L-GLUTAMIC ACID-GAMMA-BENZYL ALPHA-METHYL-DIESTER;N-ALPHA-T-BUTOXYCARBONYL-L-GLUTAMIC ACID GAMMA-BENZYL ESTER ALPHA-METHYL ESTER;Boc-L-glutamic acid γ-benzyl α-methyl ester;Boc-L-glutamicacid-benzyla-methylester;BOC-L-GLUTAMIC ACID-Y-BENZYL A-METHYL-DIESTER;BOC-L-GLUTAMIC ACID .GAMMA.-BENZYL .ALPHA.-METHYL ESTER
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CAS No:
BOC-GLU(OBZL)-OME Use and Manufacturing
Step 1 Step 1[00181] Methyl iodide (1.01 mL, 16.3 mmol) was added dropwise to a solution of (2S)-5-(benzyloxy)-2-{[(tert-butoxy)carbonyl]amino}-5-oxopentanoic acid XII (5.00 g, 14.82 mmol) and KBoc-L-Glu(OBn)OH 3 (5 g, 14.82 mmol) was added to a 50 mL round bottom flask containing acetone (25 mL).Potassium carbonate (4097 mg, 29.64 mmol) was then added. The reaction mixture wasstirred for 10 minutes and dimethylsulphate (1.55 mL, 16.3 mmol) was addedand stirred for 1 hour at rt. Thereaction was monitored by TLC and showed complete disappearance of startingmaterial. After removal of acetone, water was added and extracted with ethylacetate. The resultant organic layer was dried over sodium sulphate andconcentrated to obtain compound 4 asa colorless liquid.(4.95 g , 95percent). [α]
Computed Properties
Molecular Weight:351.4
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:11
Exact Mass:351.16818752
Monoisotopic Mass:351.16818752
Topological Polar Surface Area:90.9
Heavy Atom Count:25
Complexity:451
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes