1-[(1,1-Dimethylethoxy)carbonyl]-4-piperidinebutanoic acid

White powder

Step A To a solution of 4-(l-(tert-butoxycarbonyl)piperidin-4-yl)butanoic acid (542 mg, 2 mmol) and DIPEA (774 mg, 6 mmol) in DMF (8 mL) at 0 C was added HATU (800 mg, 2.1 mmol). After stirring at 0 C for 1 h, (R)-2-phenyl-l-((3aS, 4S, 6S, 7aR)-3a, 5, 5-trimethylhexahydro-4, 6- methanobenzo[d] [l, 3, 2]dioxaborol-2-yl)ethan-l-amine (600 mg, 2 mmol) was added. The resulting mixture was stirred at rt for 4 h, before partitioned between HC1 (1 M) and EtOAc. The organic layer was washed with aq. NaHCCb, water and brine, dried over Na2S04 and filtrated. The filtration was concentrated to dryness to afford tert-butyl 4-(4-oxo-4-(((R)-2-phenyl-l-((3aS, 4S, 6S, 7aR)-3a, 5, 5-trimethylhexahydro- 4, 6-methanobenzo[d][l, 3, 2] dioxaborol-2-yl)ethyl)amino)butyl) piperidine- 1 -carboxylate (700 mg, 66%) as an off-white solid.

Molecular Weight:271.35
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:271.17835828
Monoisotopic Mass:271.17835828
Topological Polar Surface Area:66.8
Heavy Atom Count:19
Complexity:314
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes