3-BROMO-1-METHYL-1H-PYRAZOLO[3,4-B]PYRIDINE
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![3-BROMO-1-METHYL-1H-PYRAZOLO[3,4-B]PYRIDINE structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220811/faf087ffe11a4a77b7eca41231333290.png "3-BROMO-1-METHYL-1H-PYRAZOLO[3,4-B]PYRIDINE")
3-BROMO-1-METHYL-1H-PYRAZOLO[3,4-B]PYRIDINE
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CAS No:
116855-03-9
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Formula:
C7H6BrN3
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Chemical Name:
3-BROMO-1-METHYL-1H-PYRAZOLO[3,4-B]PYRIDINE
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Synonyms:
3-bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine;3-bromo-1-methylpyrazolo[3,4-b]pyridine;1H-Pyrazolo[3,4-b]pyridine, 3-bromo-1-methyl-;NSC127451;SCHEMBL13658230;CTK4B0025;DTXSID10299004;KS-00000S2W;ZINC1715822;MFCD11878034
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CAS No:
3-BROMO-1-METHYL-1H-PYRAZOLO[3,4-B]PYRIDINE Basic Attributes
212.049
210.97500
127451
DTXSID10299004
2933990090
Characteristics
30.7
1.9
1.76±0.1 g/cm3(Predicted)
81-82 °C(Solv: methanol (67-56-1))
308.5±22.0 °C(Predicted)
3-BROMO-1-METHYL-1H-PYRAZOLO[3,4-B]PYRIDINE Use and Manufacturing
(100 mg, 0.472 mmol) is dissolved in toluene (5 mL) and tributyl(1-ethoxyvinyl)tin (187 mg, 0.519 mmol) and tetrakis(triphenylphosphine) palladium(0) (54 mg, 0.047 mmol) are added to the solution and the reaction is refluxed for 2 h. Volatiles are evaporated under reduced pressure and the resulting residue is suspended in THE/aqueous 2M HCI 1:1 andstirring is continued for lh. The reaction mixture is basified with Na2CO3 saturated solution, and extracted with ethyl acetate. The organic layer is dried, evaporated and the resulting residue is purified by flash chromatography (eluent 0-100% EtOAc/Cyclohexane) to give the title compound (70 mg, 85 %)UPLC-MS (Method 2): R = 0.78 mmMS (ESI pos): m/z = 176 (M+H)+
3-BROMO-1-METHYL-1H-PYRAZOLO[3,4-B]PYRIDINE
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