7-Bromo-1H-pyrrolo[3,2-c]pyridine

To a solution of 7-bromo-1H-pyrrolo[3, 2-C]pyridine (700 mg, 3.55 mmol) in DMF (7 mL) was added sodium hydride (171 mg, 4.26 mmol). The resulting mixture was stirred for 0.5 hours at 25 C. Methyl iodide (656 mg, 4.62 mmol) was added and stirred for 1 hour. The reaction mixture was quenched with water (30 mL) and extracted with ethyl acetate (30 mL*2). The combined ethyl acetate layers were washed with water and brine, dried over Na2SO4, and concentrated in vacuo to give 7-bromo-1-methyl-pyrrolo[3, 2-c]pyridine (640 mg, 81% yield) as a yellow solid. LCMS (ESI): [M+H]+=211.0.Sodium hydride (0.25 g, 6.2 mmol) is added under ice bath cooling to a mixture of Sodium hydride (0.25 g, 6.2 mmol) is added under ice bath cooling to a mixture of 7-bromo-lH-pyrrolo[3, 2-c]pyridine (0.8 g, 4.1 mmol) in DMF (10 ml). The mixture is stirred for 30 minutes before methyl iodide (0.25 ml, 4.1 mmol) is added. The mixture is warmed to RT and stirred for 17 h. The mixture is diluted with DCM and extracted with a saturated aqueous sodium hydrogencarbonate solution. The combined organic layers are dried over MgS04 and concentrated in vacuo. The product is purified by RP HPLC. Yield: 0.61 g (71%). HPLC-MS: tR=0.88 min (METHOD l).Production Example 46 To a mixture of

Molecular Weight:197.03
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Exact Mass:195.96361
Monoisotopic Mass:195.96361
Topological Polar Surface Area:28.7
Heavy Atom Count:10
Complexity:129
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes