5-BROMO-1H-INDAZOL-3-AMINE
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5-BROMO-1H-INDAZOL-3-AMINE
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CAS No:
61272-71-7
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Formula:
C7H6BrN3
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Chemical Name:
5-BROMO-1H-INDAZOL-3-AMINE
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Synonyms:
5-BROMO-1H-INDAZOL-3-AMINE;5-BROMO-1H-INDAZOL-3-YLAMINE;5-Bromo-1H-indazol-3-amine 95%;5-bromo-1H-indazol-3-amine (en);3-Amino-5-bromo-1H-indazole;3-Amino-5-bromoindazole;3-Amino-5-bromo-1H-indazole 95%;5-bromo-1H-indazol-3-amine(SALTDATA: FREE)
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CAS No:
Characteristics
54.7
1.9
Clear colorless Liquid
1.9±0.1 g/cm3
171-175
431.3°C at 760 mmHg
214.7±23.2 °C
1.800
Room temperature.
Safety Information
IRRITANT
25-36/37/38-22
45-36/37/39-26-22
Xi,T
Irritant
P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501
H301
|Danger|H301 (29.01%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 131 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
5-BROMO-1H-INDAZOL-3-AMINE Use and Manufacturing
Add the final product 03 (40 mg, 0.124 mmol), (636.2 mg, 3 mmol), 1-methyl-4- (4, 4, 5, 5-tetramethyl-1, 3, 2-dioxolane-2-yl) pyrazole(936.5mg, 4.5mmol) and Na2CO3 (636mg, 6mmol) were added to a 50mL reaction flask, 10mL DME was added to dissolve the reactants, and O2 was removed. A catalyst (Pd (dppf) Cl2-CH2Cl2 (245mg, 0.3mmol) was added, and O2 was removed again , Stir overnight at 100 C.The reaction was completed, filtered, and the filtrate was added with 10 mL of water and purified by HPLC.517.5 mg of the target compound was obtained.Under nitrogen protection, N- (2-methylpropenyl) -N-phenylacetamide 1a (0.2 mmol), Add 1a (53 mg, 0.5 mmol), 2i (106 mg, 0.5 mmol), triethylamine (126 mg, to a 35 mL reaction flask.1.25 mmol), ammonium iodide (108.8 mg, 0.75 mmol) and chlorobenzene (2 mL) were then placed in an oil bath at 120 C for an additional 12 h.The reaction was quenched by the addition of 50 mL of EtOAc (EtOAc)EtOAc. Filter, spin dry, separated by silica gel column (petroleum ether / acetic acid BEster = 15/1) gave a yellow solid product 3ai (116.6 mg, 72%)
Computed Properties
Molecular Weight:212.05
XLogP3:1.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Exact Mass:210.97451
Monoisotopic Mass:210.97451
Topological Polar Surface Area:54.7
Heavy Atom Count:11
Complexity:153
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
