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4-Bromo-2-chloroanisole

4-Bromo-2-chloroanisole structure

CAS No:
50638-47-6
Formula:
C7H6BrClO
Chemical Name:
4-Bromo-2-chloroanisole
Synonyms:
Benzene,4-bromo-2-chloro-1-methoxy-;4-Bromo-2-chloro-1-methoxybenzene;1-Bromo-3-chloro-4-methoxybenzene;2-Chloro-4-bromoanisole;4-Bromo-2-chloroanisole;3-Chloro-4-methoxyphenyl bromide
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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4-Bromo-2-chloroanisole Basic Attributes

Molecular Weight：

221.48

Exact Mass：

221.48

EC Number：

256-672-2

DSSTox ID：

DTXSID70198680

HScode：

2909309090

Characteristics

PSA：

9.2

XLogP3：

3.4

Density：

1.6±0.1 g/cm3

Melting Point：

70 °C

Boiling Point：

241-248 °C @ Press: 748 Torr

Flash Point：

100℃

Refractive Index：

1.556

Storage Conditions：

Room temperature.

Safety Information

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

4-Bromo-2-chloroanisole Use and Manufacturing

(RS)-4-(3-Bromo-4-fluoro-phenyl)-4-(3-chloro-4-methoxy-phenyl)-4, 5-dihydro-oxazol-2-ylamine 1) Synthesis of 4-bromo-2-chloro-1-methoxybenzene (compound 211-1) [0352] 4-Bromo-2-chlorophenol (25.0 g) was dissolved in N, N-dimethylformamide (150 ml), potassium carbonate (33.2 g) and methyl iodide (25.6 g) were added, and the mixture was stirred at 60°C for 2 hr. The reaction mixture was poured into water, extracted with ethyl acetate, washed with saturated brine, dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give compound 211-1 (26.7 g) as a pale-yellow solid. General procedure: To a reaction tube charged with NBS (1.5 equiv, 0.3 mmol), catalyst (10 molpercent, 0.02 mmol) and CH

Computed Properties

Molecular Weight:221.48
XLogP3:3.4
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:219.92906
Monoisotopic Mass:219.92906
Topological Polar Surface Area:9.2
Heavy Atom Count:10
Complexity:110
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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4-Bromo-2-chloro-1-methoxybenzene

CAS No.: 50638-47-6

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