2-(3-bromo-2,2-dimethylpropyl)-1H-isoindole-1,3(2H)-dione

Step 2To a solution of 2, 3-dihydro-lH-isoindole-l , 3-dione (3.1 g, 21.07 mmol, 1.00 equiv), 3-bromo-2, 2-dimethyipropan-l -ol (3.4 g, 23.2 mmol, 1.10 equiv), triphenylphosphane (10.9 g, 41.56 mmol, 2.00 equiv) in THF (100 mL) was loaded diisopropyl azodicarhoxylate (8.3 g, 41.09 mmol, 2.00 equiv) dropwise at 0°C under nitrogen atmosphere. The resulting solution was stirred for 12 h at 25°C. The resulting mixture was concentrated under vacuum. The residue was applied onto a silica gel column eluting with ethyl acetate / petroleum ether (1 / 50). This resulted in 3.2 g (51 percent) of 2-(3-bromo-2, 2- dirnethylpropy.)-2, 3-dihydro- 1 H-isolndole- 1. 3-dione as a colorless oil, Step 2. To a solution of 2, 3-dihydro-1H-isoindole-1, 3-dione (3.1 g, 21.07 mmol, 1.00equiv), 3-bromo-2, 2-dimethylpropan-1-ol (3.4 g, 23.2 mmol, 1.10 equiv), triphenylphosphane (10.9 g, 41.56 mmol, 2.00 equiv) in THF (100 mL) was loaded diisopropyl azodicarboxylate (8.3 g, 41.09 mmol, 2.00 equiv) dropwise at 0 °C under nitrogen atmosphere. The resulting solution was stirred for 12 h at 25 °C. The resulting mixture was concentrated under vacuum. The residue was applied onto a silica gel column eluting withethyl acetate / petroleum ether (1/50). This resulted in 3.2 g (51percent) of 2-(3-bromo-2, 2-dimethylpropyl)-2, 3-dihydro-1H-isoindole-1, 3-dione as a colorless oil.Step 2 A solution of 2 (1.0 g, 4.4 mmol), potassium phthalimide (0.4 g, 2.2 mmol) in DMF (10 mL) was stirred at 90 °C for 10 h. The mixture was poured into H

Molecular Weight:296.16
XLogP3:3.4
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:295.02079
Monoisotopic Mass:295.02079
Topological Polar Surface Area:37.4
Heavy Atom Count:17
Complexity:316
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes