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    BTZ043 structure

    BTZ043

    • CAS No:

      1161233-85-7

    • Formula:

      C17H16F3N3O5S

    • Synonyms:

      BTZ043;BTZ043 raceMate;2-[(2S)-2-Methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl]-8-nitro-6-trifluoromethyl-4H-1,3-benzothiazin-4-one;BTZ 10526043;PBTZ 169

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    Description

    BTZ043 is an inhibitor of decaprenyl-phosphoribose-epimerase (DprE1), with MICs of of 2.3 nM and 9.2 nM for M. tuberculosis H37Rv and Mycobacterium smegmatis, respectively.

    Basic Attributes

    • 1161233-85-7

    • C17H16F3N3O5S

    • 431.3862496

    • 431.076263

    • 122 A^2

    • 2.9

    • -0

    • GTUIRORNXIOHQR-VIFPVBQESA-N

    • 9

    • 0

    • 0.53

    • 1

    Characteristics

    • 1.68

    • 285.0±32.9 °C

    • 1.666

    Safety Information

    Production Methods

    A suspension of 3.0 g of 2-methylthio-8-nitro-6-trifluoromethyl-4H-1, 3-benzothiazin-4-one (compound 1) in 15 mL of ethanol was treated with 1.5 g of (2S)-2-methyl-1, 4-dioxa-8-azaspiro[4.5]decane at room temperature.4 g of 2-chloro-3-nitro-5-trifluoromethylbenzamide were treated with 3.3 g potassium xanthogenate in 80 mL ethanol at room temperature.

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