2-BROMO-5-NITROPYRIDIN-4-AMINE
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2-BROMO-5-NITROPYRIDIN-4-AMINE
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CAS No:
84487-15-0
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Formula:
C5H4BrN3O2
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Chemical Name:
2-BROMO-5-NITROPYRIDIN-4-AMINE
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Synonyms:
2-BROMO-5-NITROPYRIDIN-4-AMINE;4-Amino-2-bromo-5-nitropyridine;2-BroMo-5-nitro-4-pyridinaMine;4-AMino-2-broMo-5-nitropy...;(2-Bromo-5-nitropyridin-4-yl)amine;2-broMo-5-nitropyridin-4-aMino
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CAS No:
Safety Information
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
2-BROMO-5-NITROPYRIDIN-4-AMINE Use and Manufacturing
Step 1. 2-bromo-5-nitro-4-pyridinamine Under nitrogen, to a solution of 2, 4-dibromo-5-nitropyridine in THF (150 mL), was added ammonia (2. OM in MeOH), followed with triethylamine (5mL). This mixture was then stirred at rt for 50 h. The reaction mixture was concentrated, taken up in EtOAC, filtered through a silica gel pad, and then concentrated in vacuo to afford the title compound (3.67 g, 95percent).Step 1. 2-bromo-5-nitro-4-pyridinamine Under nitrogen, to a solution of 2, 4-dibromo-5-nitropyridine in THF (150 mL), was added ammonia (2. OM in MeOH), followed with triethylamine (5mL). This mixture was then stirred at rt for 50 h. The reaction mixture was concentrated, taken up in EtOAC, filtered through a silica gel pad, and then concentrated in vacuo to afford the title compound (3.67 g, 95percent).4-Amino-5-nitropicolinonitrile (Compound 64) A solution of 4-Amino-5-nitropicolinonitrile (Compound 64) A solution of