CAY10650
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CAY10650
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CAS No:
1233706-88-1
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Formula:
C28H25NO6
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Chemical Name:
CAY10650
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Synonyms:
CAY10650;1H-Indole-5-carboxylic acid, 3-(2-Methyl-1-oxopropyl)-1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-;3-(2-Methyl-1-oxopropyl)-1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indole-5-carboxylic acid;CAY10650, >=98%
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CAS No:
Description
CAY10650 is a highly potent cytosolic phospholipase A2α (cPLA2α) inhibitor with an IC50 value of 12 nM.IC50 value: 12 nMTarget: cPLA2CAY10650 is a highly potent (IC50 = 12 nM) cPLA2α inhibitor. It demonstrates strong anti-inflammatory effects when applied topically at a dose of 0.1 mg/ear in a mouse model of acute irritant contact dermatitis. Chinese hamsters (n = 6/group) were infected with parasite-laden contact lenses and treated with cPLA2α inhibitors (AACOCF3 and CAY10650) 50 μg/5 μ
Characteristics
94.83000
4.63
1.24±0.1 g/cm3(Predicted)
103-104℃
685.4±55.0 °C(Predicted)
368.3±31.5 °C
1.607
Computed Properties
Molecular Weight:471.5
XLogP3:5.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:10
Exact Mass:471.16818752
Monoisotopic Mass:471.16818752
Topological Polar Surface Area:94.8
Heavy Atom Count:35
Complexity:740
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes