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CGP77675

CGP77675 structure

CGP77675 

structure
  • CAS No:

    234772-64-6

  • Formula:

    C26H29N5O2

  • Chemical Name:

    CGP77675

  • Synonyms:

    CGP77675;4-Piperidinol, 1-[2-[4-[4-aMino-5-(3-Methoxyphenyl)-7H-pyrrolo[2,3-d]pyriMidin-7-yl]phenyl]ethyl]-;1-(2-{4-[4-Amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]phenyl}ethyl)piperidin-4-ol;1-(4-(4-Amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenethyl)piperidin-4-ol

Description

CGP77675 is a potent inhibitor of Src family kinases. CGP77675 inhibits Src, EGFR, KDR, v-Abl, and Lck with IC50s of 0.02, 0.15, 1.0, 0.31, and 0.29 μM, respectively. Anticancer activity[1].

CGP77675 Basic Attributes

443.551

443.23200

EQH27E0WRV

DTXSID20178033

Characteristics

89.4

4.19660

white to beige

DMSO: >10mg/mL

2-8°C

Safety Information

NONH for all modes of transport

3

Drug Information

Agents that inhibit PROTEIN KINASES. (See all compounds classified as Protein Kinase Inhibitors.)

1-(2-(4-(4-amino-5-(3-methoxyphenyl)-7H-pyrrolo(2,3-d)pyrimidin-7-yl)phenyl)ethyl)-4-piperidinol(C119957 - M000636242)

Computed Properties

Molecular Weight:443.5
XLogP3:3.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:443.23212518
Monoisotopic Mass:443.23212518
Topological Polar Surface Area:89.4
Heavy Atom Count:33
Complexity:608
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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