6-chloropyrido[3,2-b]pyrazine

Intermediate 4.2; 6-Chloro-pyrido[2, 3-blpvrazine (Scheme 10); 6-chloro-2, 3-pyridinediamine (Intermediate 4.1) (1 g, 6.96 mmol, 1 eq.) was dissolved in THF (15 mL). Glyoxal (0.84 mL, 18.1 mmol, 2.5 eq.) was added and reaction mixture stirred at rt for 2 hours. Reaction was monitored by RP-HPLC. THF was evaporated, residue re-dissolved in ethyl acetate (30 mL). Organic phases washed twice with saturated Na2C03, dried with magnesium sulfate and evaporated under vacuum to give 1.15 g of the expected compound as a white solid (Intermediate 4.2). Amount: 1.15 g; Yield: 100 percent; Formula: C7H4N3CI; HPLC Purity: 98percent; HPLC (H'Q TFA 0.1percent-ACN TFA Q.05percent): Rt (min); Area percent = 1.2 min; 98percent; 1H NMR (CDCU) 8 9.0 (s, 1H), 8.88 (s, 1H), 8.36 (d, 1H, J=8Hz), 7.67 (d, 1H, J= 8Hz); LC-MS: M/Z ESI: Rt (min) 0.68 min, 167.0 (M+l).

Molecular Weight:165.58
XLogP3:1.4
Hydrogen Bond Acceptor Count:3
Exact Mass:165.0093748
Monoisotopic Mass:165.0093748
Topological Polar Surface Area:38.7
Heavy Atom Count:11
Complexity:142
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes