7-chloroiMidazo[1,2-b]pyridazine

A solution of 5-chloropyridazin-3-amine (14.4 g, 111 mmol) and chloroacetaldehyde (81 mL, 556 mmol) in 2-propanol (150 mL) was heated at 100 °C for 16 h. The mixture was cooled to room temperature and concentrated. The residue was added water (400 mL) and washed with EtOAc (3x500 mL). The aqueous layer was taken to pH 8 with saturated NaHCO3 solution and was extracted with EtOAc (3x50mL). The combined organic layers were washed with brine, dried over Na2SO4, filtered and concentrated. The material was purified via column chromatography (40percent EtOAc/PE) to obtain 7-chloroimidazo[1, 2-b]pyridazine (10.2, 59percent yield) as a brown solid. ‘HNMR:(400MHz, CDC13) ö 8.27 (s, 1H), 7.96 (s, 2H), 7.78 (s, 1H); LCMS 154.3 (M+H).

Molecular Weight:153.57
XLogP3:1
Hydrogen Bond Acceptor Count:2
Exact Mass:153.0093748
Monoisotopic Mass:153.0093748
Topological Polar Surface Area:30.2
Heavy Atom Count:10
Complexity:130
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes