 Home > Encyclopedia > 3-(4-Chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide

3-(4-Chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide

3-(4-Chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide structure

CAS No:
472981-92-3
Formula:
C16H14ClNO2
Chemical Name:
3-(4-Chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide
Synonyms:
2-Propenamide,3-(4-chlorophenyl)-N-(3-methoxyphenyl)-;3-(4-Chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide;SB 366791
Categories:
Organic Chemistry > Amides

Description

SB-366791 is a potent , competitive and selective vanilloid receptor (VR1/TRPV1) antagonist with IC50 of 5.7±1.2 nMtarget: VR1/TRPV1IC 50: 5.7±1.2 nM [1] SB-366791 produced a concentration-dependent inhibition of the response to capsaicin with an apparent pKb of 7.74±0.08. Schild analysis indicated a competitive mechanism of action with a pA2 of 7.71.[1] SB-366791 showed a concentration-dependent potentiation of pH 5-induced 45Ca2+uptake in CHO cells expressing rat TRPV1 but not in untra

3-(4-chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide is a member of cinnamamides and a secondary carboxamide.

3-(4-Chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide Basic Attributes

Molecular Weight：

287.74

Exact Mass：

287.74

Characteristics

PSA：

38.3

XLogP3：

4.2

Appearance：

off-white solid

Density：

1.3±0.1 g/cm3

Melting Point：

165-167℃

Boiling Point：

494.2°C at 760 mmHg

Flash Point：

252.7±28.7 °C

Refractive Index：

1.650

Water Solubility：

DMSO: 13 mg/mL, soluble

Storage Conditions：

Store at RT

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

22-24/25

Drug Information

MeSH Entry Terms：

N-(3-methoxyphenyl)-4-chlorocinnamanilide

Computed Properties

Molecular Weight:287.74
XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:287.0713064
Monoisotopic Mass:287.0713064
Topological Polar Surface Area:38.3
Heavy Atom Count:20
Complexity:337
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Latest News on 3-(4-Chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide

Learn More Other Chemicals

4,4′-(1,2-Diazenediyl)bis[N,N,N-trimethylbenzenaminium]

21704-61-0
N-(4-Chloro-2-methylphenyl)formamide

21787-81-5
Basic Blue 8

2185-87-7
3-tert-butyl-5-chloro-2-hydroxy-N-(2-nitrosophenyl)benzamide Formula

21889-00-9
1-Phenylcyclohexylamine Formula

2201-24-3
6-Hydroxymelatonin Formula

2208-41-5
Pyrrocaine Structure

2210-77-7
2-amino-N-(4-ethoxyphenyl)ethanesulfonamide Structure

22103-30-6
What is Bufeniode

22103-14-6
What is 4-(2-Quinolinyl)benzenamine

22191-97-5

Hot Searches: pyrophosphate formula; bromobenzene density; natriumtripolyphosphat; ethylene glycol formula; acetate chemical formula; propylene carbonate

Guide of 3-(4-Chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Computed Properties
Latest News
Learn More Other Chemicals

3-(4-Chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide

SDS

Request for Quotation



Feedback & Suggestions

Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.