3-(4-Chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide
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3-(4-Chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide
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CAS No:
472981-92-3
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Formula:
C16H14ClNO2
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Chemical Name:
3-(4-Chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide
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Synonyms:
2-Propenamide,3-(4-chlorophenyl)-N-(3-methoxyphenyl)-;3-(4-Chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide;SB 366791
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CAS No:
Description
SB-366791 is a potent , competitive and selective vanilloid receptor (VR1/TRPV1) antagonist with IC50 of 5.7±1.2 nMtarget: VR1/TRPV1IC 50: 5.7±1.2 nM [1] SB-366791 produced a concentration-dependent inhibition of the response to capsaicin with an apparent pKb of 7.74±0.08. Schild analysis indicated a competitive mechanism of action with a pA2 of 7.71.[1] SB-366791 showed a concentration-dependent potentiation of pH 5-induced 45Ca2+uptake in CHO cells expressing rat TRPV1 but not in untra
3-(4-chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide is a member of cinnamamides and a secondary carboxamide.
Characteristics
38.3
4.2
off-white solid
1.3±0.1 g/cm3
165-167℃
494.2°C at 760 mmHg
252.7±28.7 °C
1.650
DMSO: 13 mg/mL, soluble
Store at RT
Computed Properties
Molecular Weight:287.74
XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:287.0713064
Monoisotopic Mass:287.0713064
Topological Polar Surface Area:38.3
Heavy Atom Count:20
Complexity:337
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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3-(4-Chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide
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