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Etifoxine hydrochloride

Etifoxine hydrochloride structure

CAS No:
56776-32-0
Formula:
C17H17ClN2O.ClH
Chemical Name:
Etifoxine hydrochloride
Synonyms:
4H-3,1-Benzoxazin-2-amine,6-chloro-N-ethyl-4-methyl-4-phenyl-,hydrochloride (1:1);4H-3,1-Benzoxazin-2-amine,6-chloro-N-ethyl-4-methyl-4-phenyl-,monohydrochloride;Etifoxine hydrochloride;Stresam
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Etifoxine Hcl(HOE 36-801) is potentiator of GABAA receptor function in cultured neurons. Etifoxine preferentially acts on β2 or β3 subunit-containing GABAA receptors. IC50 value:Target: GABAA receptorEtifoxine exhibits anxiolytic activity in rodents and humans with no sedative, myorelaxant or mnesic side effects. Etifoxine acts as a ligand of the translocator protein (TSPO); promotes axonal regeneration.

Etifoxine hydrochloride Basic Attributes

Molecular Weight：

337.24362

Exact Mass：

336.079620

EC Number：

260-380-0

Characteristics

PSA：

33.6

XLogP3：

4.85920

Appearance：

white to beige

Density：

1.2g/cm3

Melting Point：

150-151 °C

Boiling Point：

421.2ºC at 760mmHg

Flash Point：

208.5ºC

Storage Conditions：

Desiccate at +4°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

Marks：

Precautionary statement(s)：

P264, P270, P280, P301+P312, P305+P351+P338, P310, P330, P501

Hazard Statements：

H302

GHS Classification：

|Danger|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P280, P301+P312, P305+P351+P338, P310, P330, and P501|Aggregated GHS information provided by 158 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)

MeSH Entry Terms：

2-ethylamino-6-chloro-4-methyl-4-phenyl-4H-3,1-benzoxazine

Etifoxine hydrochloride Use and Manufacturing

Psychotropic agent with anxiolytic and anticonvulsant activity.

Computed Properties

Molecular Weight:337.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:336.0796186
Monoisotopic Mass:336.0796186
Topological Polar Surface Area:33.6
Heavy Atom Count:22
Complexity:394
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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HOE-36801 hydrochloride

CAS No.: 56776-32-0

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Etifoxine hydrochloride 56776-32-0

Unit Price: $12 /UNIT EXW

CAS No.: 56776-32-0

Grade: Pharmaceutical Grade

Content: 98%

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