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3-Chloro-5-methoxybenzenamine

3-Chloro-5-methoxybenzenamine structure

CAS No:
10272-06-7
Formula:
C7H8ClNO
Chemical Name:
3-Chloro-5-methoxybenzenamine
Synonyms:
Benzenamine,3-chloro-5-methoxy-;m-Anisidine,5-chloro-;3-Chloro-5-methoxybenzenamine;3-Chloro-5-methoxyaniline
Categories:
Chemical Reagents > Organic Reagents

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3-Chloro-5-methoxybenzenamine Basic Attributes

Molecular Weight：

157.59752

Exact Mass：

157.60

EC Number：

233-614-4

DSSTox ID：

DTXSID60145466

HScode：

2922299090

Characteristics

PSA：

35.2

XLogP3：

2.5

Density：

1.234±0.06 g/cm3(Predicted)

Melting Point：

33 °C

Boiling Point：

280.3±20.0 °C(Predicted)

Flash Point：

123.3±21.8 °C

Refractive Index：

1.573

Safety Information

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

3-Chloro-5-methoxybenzenamine Use and Manufacturing

Methods of Manufacturing

General procedure: To a solution of ethyl 4-bromo-1H-indole-2-carboxylate in toluene underargon atmosphere was added Pd2(dba)3 (0.1 eq), DavePhos (0.2 eq), K3PO4 (3 eq, 1Maqueous solution) and aryl amine (3 eq), and then the mixture was reacted at 80 Cuntil the starting material disappeared. The mixture was cooled to room temperatureand concentrated. Ethyl acetate was added to dissolve the residue and the mixture waswashed with saturated brine and water, dried over anhydrous Na2SO4, andconcentrated in vacuo. The crude product was purified by column chromatography toafford the target compound. Compounds 8a-8f, 8i-8l, 8a-1, 8a-6 ~ 8a-11, 8a-14 wereprepared with method 1.

Uses

3-Chloro-5-methoxyaniline is an intermediate used in the synthetic preparation of various pharmaceutical goods.

Computed Properties

Molecular Weight:157.60
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:157.0294416
Monoisotopic Mass:157.0294416
Topological Polar Surface Area:35.2
Heavy Atom Count:10
Complexity:110
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 3-Chloro-5-methoxybenzenamine

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
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Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

3-chloro-5-methoxyaniline

CAS No.: 10272-06-7

Content: 99.00%

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Compound Net Biotechnology Inc. Contact Supplier

CN
YRS

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Manufactory Supplier of 4-(Pentafluorothio)aniline,Pentafluoro,Pentafluorothio,Pentafluorosulfur,[4-(bromomethyl)phenyl]-pentafluoro-lambda6-sulfane,[4-(pentafluoro-sulfanyl)phenyl]acetic acid

10272-06-7 3-chloro-5-methoxyaniline

CAS No.: 10272-06-7

Grade: Industrial Grade

Content: 95%

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Guide of 3-Chloro-5-methoxybenzenamine

Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Learn More Other Chemicals

3-Chloro-5-methoxybenzenamine

SDS

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