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Cloranolol

Cloranolol structure

CAS No:
39563-28-5
Formula:
C13H19Cl2NO2
Chemical Name:
Cloranolol
Synonyms:
2-Propanol,1-(2,5-dichlorophenoxy)-3-[(1,1-dimethylethyl)amino]-;1-(2,5-Dichlorophenoxy)-3-[(1,1-dimethylethyl)amino]-2-propanol;Tobanum;1-tert-Butylamino-3-(2,5-dichlorophenoxy)-2-propanol;Chloranolol;Cloranolol;64969-29-5
Categories:
Organic Chemistry > Amides

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Description

White Solid

Cloranolol is a dichlorobenzene.

Cloranolol Basic Attributes

Molecular Weight：

292.2

Exact Mass：

292.20

ATC Code：

C - Cardiovascular system

HScode：

2922509090

Characteristics

PSA：

41.5

XLogP3：

3.51210

Density：

1.201g/cm3

Melting Point：

82-83 °C

Boiling Point：

408.3ºC at 760 mmHg

Flash Point：

200.7ºC

Refractive Index：

1.533

Drug Information

MeSH：

Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety. (See all compounds classified as Adrenergic beta-Antagonists.)|Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

MeSH Entry Terms：

1-(2,5-dichlorophenoxy)-3-tertiary-butylamino-2-propanol

Cloranolol Use and Manufacturing

Chloranolol is a β-adrenergic blocher. Chloranolol is used as an antiarrhythmic.

Computed Properties

Molecular Weight:292.20
XLogP3:3.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:291.0792842
Monoisotopic Mass:291.0792842
Topological Polar Surface Area:41.5
Heavy Atom Count:18
Complexity:246
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes