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1-(4-chloropyridin-2-yl)ethanone

1-(4-chloropyridin-2-yl)ethanone structure

CAS No:
60159-37-7
Formula:
C7H6ClNO
Chemical Name:
1-(4-chloropyridin-2-yl)ethanone
Synonyms:
1-(4-chloropyridin-2-yl)ethanone;1-(4-Chloropyridine-2-yl)ethanone;2-Acetyl-4-chloropyridine;1-(4-chloropyridin-2-yl)ethan-1-one;1-(4-Chloro-2-pyridinyl)-ethanone;1-(4-Chloro-2-pyridyl)ethanone;1-(4-Chloropyridine-2-yl)
Categories:
Chemical Reagents > Organic Reagents

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1-(4-chloropyridin-2-yl)ethanone Basic Attributes

Molecular Weight：

155.58

Exact Mass：

155.013794

DSSTox ID：

DTXSID70515111

HScode：

2933399090

Characteristics

PSA：

XLogP3：

1.5

Density：

1.2±0.1 g/cm3

Boiling Point：

238℃

Flash Point：

98℃

Refractive Index：

1.535

Safety Information

Hazard category：

IRRITANT

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, P501

Hazard Statements：

H302+H312+H332

GHS Classification：

|Warning|H302+H312+H332 (50%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

1-(4-chloropyridin-2-yl)ethanone Use and Manufacturing

Step A2-Acetyl-4-chloropyridine: 2-Acetyl-4-chloropyridine: Preparation 7 1 -(4-Chloro ridin-2-yl)ethanone Methyl magnesium bromide (3 M in diethyl ether) (59 mL; 177.20 mmol) is added to anhydrous tetrahydrofuran (150 mL) with stirring under nitrogen. The resulting solution is cooled to -15 °C and a solution of 4-chloro-N-methoxy-N-methyl-pyridine-2- carboxamide (23.7 g 1.00 118.13 mmol) in anhydrous tetrahydrofuran (150 mL) is added drop wise over 20 minutes keeping the temperature between 0 and -15 °C. After this addition is complete the reaction is stirred at 0 °C for 45 minutes. The reaction is then cooled to -15 °C and is slowly quenched by careful drop wise addition of water (250 mL). Saturated aqueous ammonium chloride solution (250 mL) and diethyl ether (200 mL) are added. The layers are separated and the aqueous layer is re-extracted twice with diethyl ether (200 mL). The combined organic extracts are dried over anhydrous sodium sulphate, filtered, and the solvent is removed under reduced pressure to give the title compound as a yellow oil (18.6 g). ES/MS 156/158 (M+l).

Computed Properties

Molecular Weight:155.58
XLogP3:1.5
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:155.0137915
Monoisotopic Mass:155.0137915
Topological Polar Surface Area:30
Heavy Atom Count:10
Complexity:138
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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1-(4-chloropyridin-2-yl)ethanone

CAS No.: 60159-37-7

Content: 99.00%

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60159-37-7 1-(4-chloropyridin-2-yl)ethanone

CAS No.: 60159-37-7

Grade: Industrial Grade

Content: 95%

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Guide of 1-(4-chloropyridin-2-yl)ethanone

Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Latest News
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1-(4-chloropyridin-2-yl)ethanone

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